Sachin Chandavarkar
PES s Rajaram and Tarabai Bandekar College of Pharmacy, India
Title: Evaluation of Nephroprotective activity of methanolic extract of Biophytumsensitivum
Biography
Biography: Sachin Chandavarkar
Abstract
In this study, methanolic extract of whole plant of Biophytumsensitivum was evaluated for their nephroprotective activity using wistar albino rats. The methanolic extract was administered orally at a dose of 200 mg/kg and Gentamicin was administered at a dose of 40 mg/kg i.p. to the rats for 7 days. On eighth day all the animals were sacrificed and blood was collected to evaluate urea and creatinine level in the serum and it was taken as the index of nephrotoxicity. Histopathological examinations of kidneys of all the groups were carried out and the findings revealed that methanol extracts of Biophytumsensitivum possesses nephroprotective activity. The elevations of serum urea and creatinine produced by Gentamicin were considerably reduced and showed histopathological changes in the kidneys to normal. The study concluded that methanolic extract of Biophytumsensitivum possess nephroprotective activity.
Keywords: Biophytum sensitivum,Gentamicin, nephroprotective activity.