Alla Khosrovyan
University of Cadiz, Spain
Title: Assessment of medicinal potential of Ornithogalum transcaucasicum
Biography
Biography: Alla Khosrovyan
Abstract
This preliminary study is the first to evaluate the influence of small-weight proteins and peptides extracted from the bulb of Ornithogalum transcaucasicum on the inhibition of growth of E.coli K-12 and neural activity of the vasomotor center on Albino rat. Gel filtration chromatography was used for separation and collection of protein and peptide fractions based on 30-min time intervals. As a sorbent, sephadex (G-25) was applied. Samples were filtered and those having molecular weight less than 10 kDa were further used in biotests for examining medicinal potential. Biotest with E.coli K-12 revealed no suppressing effect on bacterial growth. Biotest with Albino test revealed stimulating and suppressing effect, dependent on fractions, on the spike activity of the vasomotor center (suppression reached 0.25 spikes/s). While the mechanism of the action of these peptides is not clear (e.g., direct effect on the diameter of vessels or through hormonal activity) and further investigation is necessary, the results demonstrate potential for the application of these extracts in a relevant medical case.