3^rd World Congress on Medicinal Plants and Natural Products Research October 02-03, 2017 Kuala Lumpur, Malaysia

Biography:

After completion of his postdoctoral training at University of Texas MD Anderson Cancer Center, Prof. Gautam Sethi joined Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. The focus of his research over the past few years has been to elucidate the mechanism (s) of activation of oncogenic transcription factors such as NF-kB/STAT3 by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted in more than one hundred and fifty scientific publications in high impact factor peer reviewed journals and several international awards. He currently serves as an Academic Editor for PLOS, editorial board member of Scientific Reports, and ad-hoc reviewer for several other international journals.

Abstract:

STATs comprise a family of cytoplasmic transcription factors that transmit signals, mediate intracellular signaling usually generated at cell surface receptors and transmitted to the nucleus. Numerous studies have demonstrated constitutive activation of  STAT3 in a  wide variety of human tumors, including blood malignancies (leukemias, lymphomas, and multiple myeloma) as well as solid tissues (such as head and neck, breast, lung, gastric, hepatocellular and prostate cancers). There is a strong evidence to suggest that aberrant STAT3 signaling promotes development and progression of human cancers by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metastasis. However, the development of novel drugs for the targeting STAT3 that is both safe and efficacious remains an important scientific and clinical challenge. We will present the data that shows that novel small molecule inhibitors of STAT3/JAK2 pathway can suppress the expression of genes involved in cancer initiation, and promotion both in vitro and in vivo. 

Biography:

MB. Rezaee, has extended his valuable service as an professor in Department of Medicinal Plants in Research Institute Forests and Rangelands. MB. Rezaee international experience includes various programs, contributions and participation in different countries for diverse fields of study.  His research interests as a professor reflect in his wide range of publications in various national and international journals. Currently he is working on extraction and purification of components from Medicinal, Aromatic and Poisonous plants by different method, and have cooperation with different professor to see it affection as natural products.

Abstract:

Medicinal and aromatic plants are offered in a wide variety of products on the world market. Iran, located in Middle East, played a key role in connecting various cultures and civilizations. Ethno-herbal and phyto- chemical dates back to a long time ago and a number of writings regarding this issue are left by great physicians e.g. Avicenna and Rhazes. Iranian botanists have recognition of around 1450 genera and 8000 species which nearby 2000 species are endemic. Iranian traditional medicine had cited pharmaceutical dosage forms, e.g. powders, syrups, ointment, extracts, powders, mucilage’s, nectars, etc. In this presentation Phyto-chemical screening of Aromatic plants, e.g. Rosa damascena, Thymus spp, Anthemis spp, Hypercom spp, are reviewed. Also the effect of ecological zone of growing, methods of extraction and identify their components are in our project. Rosa damascena cultivated in extensive zone of Iran and produce rose water and essential oils out of it. In this research, few samples of essential oil were extracting by different methods, e.g. traditionally, industrial and laboratory scales.  Samples of oil were analyzed by GC and GC/MS. The main constituents of oil by traditionally , Ghatran Gool Co. were n-nonadecane (33.1%); geraniol (14.6%), n-heneicosane (13.2%);  Kashan  sample  were shown,  n-nonadecane (33%); n-heneicosane (18.1%); mehyl hexadecane (12.9%), Laboratory essential oils samples were extracted by two hydro distillation method which designed by authors in Research Institute of Forests and Rangelands which were named plan-1 and plan-2.  The main isolated constituents in plan-1 were geraniol (21.8%), n-nonadecane (21.3%); citronellol (12%), with yield of (0.015%) and in  plan-2 were   n-nonadecane (21.8%);  geraniol (19.1%), citronellol (15%), with yield of (0.023%).in other studies,  investigated the effect of storage and time on essential oil composition  in normal temperature of Rosa demascena were down. We used different vessels e.g.  glass, color glass and aluminum quality. Main components of Primary essential oils were  citronellol (33.5%), cis-p-menth -2-en-1-ol (7.3%) and geraniol (7.2%). Storage in three months in simple glass in refrigerator were better than others methods. Storage of essences in six months of periods of time in simple glass and normal temperature is better than other. In this presentation also shown how verity, ecotype, different part of plants and methods, effected on the essentials oil of other aromatic plants name in up.

Biography:

Saad Tayyab completed his PhD in 1987. At present he is working as a Professor of Biochemistry in the University of Malaya, Malaysia. He is having 34 years of research experience in the field of biochemistry. He has published 1 book and more than 115 Research papers in various National and International Journals. He is serving as an Editorial Board Member and Reviewer of National and international journals.

Abstract:

Statement of the Problem: Several bioactive constituents of medicinal plants have been shown to possess various therapeutic properties, such as anticancer, antimicrobial, antiviral, anti-inflammatory, hepatoprotective, antioxidant, antinociceptive, antidermatophytic and immunostimulatory activities. Pharmacokinetic and pharmacodynamic properties of a therapeutic compound may be greatly influenced by its binding to the transport proteins in human blood circulation. The purpose of this study was to characterize the interaction of three pharmacologically active phytochemicals from the Zingiberaceae family, namely, flavokawain B (FB), pinostrobin S (PS) and 6-shogaol (6S) with the major transport protein, human serum albumin (HSA) of human blood circulation.

Methodology: Spectroscopic techniques such as fluorescence and circular dichroism along with molecular docking were used to study the binding characteristics of flavonoid-HSA interaction, identification of the binding site and the effect of binding on protein structure and stability.

Findings: These ligands were found to form a complex with the protein through moderate binding affinity as the values of the binding constants were found to fall in the range of 10⁴-10⁵ M^-1. The complexes were supposed to be stabilized by hydrophobic and van der Waals forces along with hydrogen bonds. Binding of these compounds to HSA increased protein’s thermal stability but produced microenvironmental alterations around protein fluorophores. Whereas FB and PS exhibited binding preference towards site I, 6S was demonstrated to bind both sites I and II, as revealed by competitive drug displacement results and molecular docking analysis. 

Conclusion & Significance: Binding characteristics of these compounds were for the most part similar and comparable to many other phytochemicals. Investigations on the binding of such therapeutic compounds to HSA are of importance in understanding chemico-biological interactions in clinical research and drug design. These results may be helpful in predicting the pharmacokinetic profiles of FB, PS and 6S as well as other structurally similar molecules.