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Day 2 :

Keynote Forum

Michael Ian Rothenberg

The Center for Counseling and Sexual Health, Florida

Keynote: Understanding Sex and Sexuality in Palliative Care; Establishing a Dialogue at the End of Life
 International Conference Keynote Speaker Michael Ian Rothenberg photo
Biography:

Michael Ian Rothenberg, Ph.D, LCSW is a Board Certified Clinical Sexologist, Certified Sex Therapist, Psychotherapist and the Founder and Clinical Director of the Center for Counseling and Sexual Health of Winter Park, Florida. As a sexuality educator, Dr. Rothenberg has held a long term faculty position, in Orlando, Florida, at the University of Central Florida (UCF), School of Social Work, where he developed the curriculum in Human Sexuality and taught courses on human sexuality and sexual behavior. Dr. Rothenberg, a former Hospice Social Worker, credited with developing the Sexological sub-field of Thanatological Clinical Sexology (the study of sexuality, death and dying), has published and been quoted in numerous articles relating to human sexuality and lectures, both nationally and internationally, at universities, hospitals and hospices, on topics related to human sexuality, sexual behavior and sexual health. 

 

Abstract:

Introduction: Human beings are sexual beings from birth until death. This presentation explores sex and sexuality at the end of life and the importance of establishing a dialogue between patients and clinicians as an integral part of end of life care. Objectives: To identify and understand barriers and challenges in discussing sex and sexuality at the end of life and establish a methodology for better communication.Methods: A qualitative methodological approach was utilized and the resultant data will be presented as case histories gathered in the context of clinical sexology consultations.Results: As discomfort and physical pain, at the end of life, can be controlled through the proper use of medication, psychological and emotional distress, directly and indirectly, related to sex and sexuality, can be ameliorated through specific conversation and dialogue. Conclusion: This presentation hopes to raise important questions about the palliative care professional's responsibility regarding the understanding of sexuality for individuals in the end of life stage as well as illustrate how to begin to engage in needed discussions on sex and sexuality.

 

 International Conference Keynote Speaker Shin-ichi Kayano photo
Biography:

Shin-ichi Kayano graduated from the Department of Food Science and Nutrition, Faculty of Human Life Science, Osaka City University, Japan, in 1985. He worked as a Senior Researcher of research institute, Miki Corporation, Japan, from 1985 through 2004. His job in Miki Corporation was the development of new products of functional foods, and study on functional components in fruits and vegetables. He was awarded a PhD in Science in 2004, from Osaka City University, Japan, under the supervision of Professor Nobuji Nakatani. He joined the Kio University as a Professor in 2009. His current study is on the antioxidative, antimutagenic, and estrogenic ingredients in various fruits and vegetables, and the elucidation of chemical structures and action mechanism of these compounds.

Abstract:

Dried fruits of persimmon (Diospyros kaki Thunb.) are a traditional food in Japan and contain large quantities of tannins. In this study, we investigated the in vitro and in vivo antioxidant potentials of non-extractable fractions from dried persimmons. Hydrolysed non-extractable fractions showed the highest antioxidant activities in vitro. In subsequent experiments, the plasma oxygen radical absorbance capacity (ORAC) values in rats supplemented with 5% non-extractable fraction were approximately 1.5 times higher than those in control rats after 1 week in vivo. Furthermore, using an in vitro model of the gastrointestinal tract, the ORAC values of the non-extractable fraction were significantly increased with colonic fermentation in the large bowel stage. These data indicate that non-extractable fractions may possess significant antioxidant potential in vitro and in vivo.

 

 International Conference Keynote Speaker Magnus S Magnusson  photo
Biography:

Magnus S Magnusson, Research Professor. PhD in 1983, University of Copenhagen. He is the author of the T-pattern and the T-systeem model, initially focused on the real-time organization of behavior, that forms the basis of his corresponding dedicated pattern detection software THEMEtm. He has co-directed a two year DNA analysis project. He has published numerous papers and given invited talks and keynotes at international athematical, neuroscience, proteomics, A.I., bioinformatics and science of religion conferences and at leading universities in Europe, USA, and Japan. Deputy Director 1983-1988, Anthropology, National Museum of Natural History, Paris. Then he has repeatedly invited temporary university Professor in psychology and ethology (biology of behavior) at the University of Paris (V, VIII & XIII). Since 1991, founder and director of the Human Behavior Laboratory, University of Iceland. He Works in formalized collaboration between now 32 European and American universities based on “Magnusson’s analytical model” initiated at University René Descartes Paris V, Sorbonne, in 1995.

 

Abstract:

This talk concerns spatial and temporal self-similarity across more than nine orders of magnitude, implicating a self-similar fractal-like pattern, called T-pattern, a natural or pseudo-fractal pattern, recurring with statistically significant translation symmetry. The T-pattern, the core of the T-system of structural concepts is a result of an ethological (i.e. biology of behavior)  project started in the early 1970’s primarily on social interaction and organization in social insects and primates including humans inspired mainly by the ethological work of Lorenz, von Frisch and Tinbergen for which they shared a Nobel Prize in Medicine or Physiology in 1973. Notably, in this context, their smallest subjects were social insects and thus no consideration of selfsimilarity. The present project has focused on developing time pattern definitions with corresponding detection algorithms resulting in the T-pattern type and the dedicated THEME software, which has allowed their abundant detection in many kinds of animal and human behavior and interactions and later in neuronal interactions within living brains, thus showing T-patterned self-similarity of temporal  interaction between and within brains. The RNA world invented its evolving external memory as the purely informational giant T-patterned DNA strings and now there is only a DNA world. Similarly, billions of years later,humans invented their evolving external memory as the purely informational T-patterned strings (T-strings) of written language that have made possible, in a biological eye-blink, the development of modern science and technology and the creation of extremely populous and complex human mass-societies, the only mass-societies among large-brained animals and recent discoveries of the nanoworld of cells and molecules. Protein and human mass-societies seem to be the only ones using such durable giant T-strings external to their citizens. Human and protein  masssocieties create their specialized citizens using various sub-sections of such T-strings, not found, notably in social insect societies. Extensive temporal and spatial self-similar patterning thus seems to exist in form and function from nano to human temporal and spatial scales suggesting structural, functional and organizational principles.

 

 International Conference Keynote Speaker Giovanni Abatangelo photo
Biography:

Full Professor of Histology and Embriology, University of Padova, Italy.

Graduated as MD (University of Padua, 1965), Postodctoral Specialization in Clinical Pathology (University of Padua, 1977), Postdoctoral Fellow Dept. of Biochemistry, Baylor University of Baylor, Houston, Texas, Usa, (1965-1967), Lecturer, Institute of Histology, University of Padua (1970), Full Professor of Histology - Embriology, University of Padua (1975 - 2011)

Senior Researcher of the Faculty of Medicine- University of Padova (2012- present)
President of the Italian Society of Cutaneous Biology and Member of the Editorial Board of "Wound Repair and Regeneration" (Mosby Inc., St. Louis MO, USA).

Abstract:

Introduction

Giovanni Abatangelo, Senior Researcher, University of Padova, Faculty of Medicine, Italy

Nociceptive pain is one of the most common types of pain and originates with an injury involving nociceptors. About 60% of the knee joint innervations are classified as nociceptive. The specific biological mechanism underlying the regulation of nociceptors is relevant for symptom treatment of pathologies affecting the knee joint. Indeed, intra-articular administration of exogenous hyaluronic acid (HA) in osteoarthritis (OA) seems to be particularly effective reducing pain and improving patient function. In the present work we investigated if HA induces activation of opioid peptide (OP) receptors.

Methods

In the present work we used both aequorin technology and the fluorescent dye Fura-2 to investigate if HA is able to induce putative antinociceptive effects via opioid receptor activation.

Results

Treatment with medium molecular weight (200 kDA) HA induces the selective activation of the kappa (KOP) receptor.

Conclusions

The relief of pain associated with HA treatment appears to be a direct action of HA to a specific antinociceptive receptor such as the KOP receptors present in the plasma membrane of nociceptors.

 International Conference Keynote Speaker Robert P Foglia photo
Biography:

Robert P Foglia, MD is Professor of Surgery and Pediatrics, Chief of Pediatric Surgery at the University of Southwestern Medical Center and Surgeon-in-Chief at Children’s Medical Center Dallas. He is Co-editor of a major textbook of pediatric surgery and has 30+ years of experience in Perioperative Management and Performance Improvement. He is responsible for the clinical growth of surgical programs at Children’s and Leads Process Improvement Initiatives in the areas of quality, service and stewardship. 

Abstract:

Our health system had a strategic plan to recruit surgeons, develop new programs and shift volume outside of the Main OR (MOR) suite. Previously, many of perioperative processes were dysfunctional, data with paper charting often had inaccuracies, and physicians had a healthy skepticism of the data, leading to a lack of engagement. Our aims included optimizing space, personnel, and processes, developing performance metrics, setting clear expectations for resource allocation and sharing credible data with stakeholders. Perioperative performance improvement is the orchestration of a multidisciplinary team to achieve a series of goals, which are sustainable. Three elements were essential to achieve these goals, prompt communication with shared goal expectation, operations management, and the electronic health record (EHR).

The results from 2006 to 2015 were: a) cases increased from 19,148 to 29,308 (53%), b) block utilization increased from 47% to 72% (+53% ), c) on time starts increased six-fold (12% to 80%), d) case cancellations reduced 3-fold (14% to 4%), e) MOR cases increased +2%, f) cases outside of MOR increased from 5,606 to 15,443 (+175%), while MOR cases increased 2%, g) revenue increased 99%, from $116M to $231M in 2015. Prompt and consistent communication with physicians and perioperative leadership, the use of operations management to change processes, and the EHR resulted in marked improvement in multiple performance metrics and a concomitant increase in engagement and "buy in" by physicians, administrative and nursing leadership.

 International Conference Keynote Speaker Rudolf Lucas photo
Biography:

Rudolf Lucas obtained his PhD in cellular and genetic biotechnology in 1993 summa cum laude from the Free University of Brussels, Belgium (VUB) and he currently holds a faculty position at the Medical College of Georgia. He is currently Chair of the American Heart Association Lung Fellowship Committee. His expertise mainly

lies in the development of novel therapeutic candidates to treat pulmonary edema. Over the past 20 years, his research has led to the discovery of a TNF-derived peptide, Solnatide, which is a direct activator of the epithelial sodium channel. This peptide has shown promising activities in two recently finalized phase 2a clinical trials in patients with acute lung injury and upon lung transplantation.

 

Abstract:

Efficient exchange of oxygen and carbon dioxide between the lung capillaries and the alveoli requires that the latter is kept dry. Vectorial Na+ transport through the apically expressed epithelial sodium channel (ENaC), and the basolaterally expressed Na+-K+-ATPase mediates Alveolar liquid Clearance (ALC) in type 1/2 alveolar epithelial cells. ENaC activity is defined by the product of its open probability time and its membrane surface expression. The alpha subunit of ENaC also associates with the acid-sensing ion channel to form the hybrid Non-Selective Cation (NSC) Channel, which also contributes to ALC. In conditions of ARDS and severe pneumonia, which are associated with intense pulmonary inflammation, ENaC function can become impaired. Moreover, pathogen-associated toxins, as well as pro-inflammatory cytokines can disrupt capillary endothelial barriers, causing fluid to leak from the capillaries into the alveolar space. The resulting Pulmonary Permeability Edema (PPE)

is a potentially lethal complication, for which no proven pharmacological treatment exists to date. The identification of novel

therapeutics for PPE is therefore of the utmost importance. Solnatide is a TNF-derived peptide that mimics the lectin-like domain of tumor necrosis factor, the latter of which is spatially distinct from the receptor binding sites1-4. Solnatide binds to the alpha subunit of ENaC and as such increases the open probability, as well as surface expression of the channel, even in the presence of bacterial toxins, such as Pneumolysin (PLY), the main virulence factor of Streptococcus pneumoniae. The peptide also prevents bacterial toxin-induced endothelial barrier dysfunction in lung microvascular endothelial cells, which express both ENaC and NSC channels and has potent anti-inflammatory actions. The therapeutic potential of Solnatide was recently evaluated in two phase clinical trials in patients with acute lung injury and lung transplantation. The results of the pre-clinical and clinical studies will be discussed in this contribution.

 

 International Conference Keynote Speaker Abuzar Kabir photo
Biography:

Abuzar Kabir is a Research Assistant Professor in the Department of Chemistry and Biochemistry, Florida International University (FIU), Miami, Florida, USA.
His research interest primarily focusses on synthesis and applications of novel sol-gel derived advanced material systems (chromatographic stationary phases,
surface coatings of high-efficiency microextraction sorbents, nanoparticles, microporous and mesoporous functionalized sorbents) for analyzing polar, medium
polar, nonpolar, ionic analytes, heavy metals and organometallic pollutants from biological/pharmaceutical/clinical/environmental sample matrices. He is an ardent
advocate of Green Analytical Chemistry (GAC). His recent inventions, fabric phase sorptive extraction (FPSE), dynamic fabric phase sorptive extraction (DFPSE),
Capsule Phase Microextraction (CPME), substrate-free liquid chromatographic stationary phases and extraction sorbents, organic polymeric liquid chromatographic
stationary phases and extraction sorbents and universal molecular imprinting technology have drawn tremendous interests among the researchers. He has published
more than 50 peer-reviewed journal articles, 9 book chapters and 90 conference proceedings. Dr. Kabir has invented numerous chromatographic stationary phases
and sample preparation technologies, resulting in 15 US patents.

Abstract:

Statement of the Problem: The invention of fabric phase sorptive extraction (FPSE) has begun a new era in analytical sample
preparation by ingeniously combining two competing for sample preparation techniques, solid phase extraction (SPE) and solid
phase microextraction (SPME) into a single sample preparation technology platform. The integrated system, FPSE utilizes a
flexible, yet active fabric (cellulose, polyester and fiberglass) substrate to host a thin layer of sol-gel derived extracting sorbent.
The engineered selectivity of the sol-gel sorbents and the hydrophobicity/hydrophilicity of the fabric substrate synergistically
complement to the net polarity of the fabric phase sorptive extraction medium and consequently, determine its extraction
efficiency. The sponge-like porous architecture of sol-gel extraction sorbent and the inherent permeability of the fabric create an
extraction medium that mimics a solid phase extraction disk and allows permeating aqueous sample matrix through its body,
leading to rapid sorbent-analyte interaction and subsequent successful retention of the analyte(s) onto the extraction medium.
The flexibility of the FPSE medium permits direct insertion into the sample container for analyte extraction and thus minimizes
the number of transfer containers used in the sample preparation process. The sol-gel coating technology allows utilization of
typical functional ligands commonly used in solid phase extraction such as C8/C18 as well as polymers used in solid phase
microextraction such as polydimethylsiloxane (PDMS). Unlike SPE and SPME, FPSE can be performed either in equilibrium
extraction mode (as in SPME) or inexhaustive extraction mode (as in SPE). In addition, sol-gel coated sorbents demonstrate
superior thermal, solvent and pH stability (1-13) compared to conventional sorbents. Due to these unmatched advantages,
FPSE has gained considerable popularity in a short period and has demonstrated numerous applications in a wide variety
of samples including food, biofluids, wastewater and air. In the current talk, analytical data pertaining to some fascinating
applications of FPSE will be presented.

 International Conference Keynote Speaker Aggeliki Pappa photo
Biography:

Αggeliki Pappa is the Founder of “i love dyslexia” (ILD), the first and only highly specialized, innovative edu-organization internationally, for holistic EFL-FL teaching to students with dyslexia and SEN. She has built ILD innovative tools and holistic study program after years of research, innovative edu-practice and teaching, and she collaborates with Folkuniversitetet, Uppsala on European projects as a Teacher Trainer. ILD has been nominated for UNESCO Hamdan Prize, was included in the top 10 innovations in Greece by ‘Greece Innovates’ competition and has have been recognized by the Greek Ministry of Education and the Ministry of Development. She was included in the Top 50 educators in the world for the Global Teacher Prize-2016 and is the Leader of the Varkey Teachers Ambassadors literacy group, collaborating with Prof. Reimers, Harvard, USA. Her passion and vision is the creation of quality education for all, for sustainability, love and peace in the world.

Abstract:

According to “Dyslexia International” 10 to 15% of global population has dyslexia, putting more than 700 million children and adults worldwide at risk of life-long illiteracy and social exclusion. A major problem of today’s education for students with dyslexia and special educational needs (SEN) is education system constraints which prevent learners from being effectively included in the learning process of a foreign language (FL) depriving them of a necessary life skill and a global voice. There is no common European methodology on teaching English as a foreign language (EFL) and FL to students with SEN, with the big majority of educators lacking awareness and practical knowledge on this still quite unexplored field. The award winning ‘i love dyslexia’ (ILD) in Athens, Greece is the first and only internationally, highly specialized school for holistic EFL-FL learning to students (children and adults) with dyslexia and SEN, introducing an innovative combination of authentic and complete FL tool collection and a pioneering multi-level program set to fill the big gap for effective EFL-FL access for millions of students with SEN worldwide, while its system could be implemented in settings where English is taught as a first language. ILD highly structured tool combination and holistic program of studies are designed based on brain targeted teaching, shelf awareness sessions, design thinking and mind mapping, smart multisensory mnemonics, synthetic and analytic teaching, drama and project passed differentiated activities, use of new technology and augmented reality tools in combination with activities in outdoor natural environment, as well as mindfulness and Aikido as educational tools to develop inner harmony and meet challenges of living to thrive in life. Last but not least, ILD provides experiential training courses on EFL-FL and SEN, empowering educators worldwide with practical knowledge and effective tools to support all their students succeed in EFL-FL learning.

 International Conference Keynote Speaker Azza Mahmoud Kamel photo
Biography:

Azza Mahmoud Kamel is currently working as Emirate Professor of Clinical Pathology at National Cancer Institute, Cairo University, Egypt since 2007. Previously she worked as Professor of Clinical Pathology (1986- 2007) at National Cancer Institute, Cairo University, Egypt, Founder and Head of BMT Lab. Unit (1993- 2007) and Head of Clinical Pathology Department (2005-2007). She pursued her Medical Degree (MB, BCh), Faculty of Medicine, Cairo University (June 1968), Master Degree (MSc) in Clinical Pathology, Faculty of Medicine, Cairo University (October 1972) and Doctorate Degree (MD) in Clinical Pathology(Immunology/ Hematology), Faculty of Medicine, Cairo University (July 1976). She has 165 publications in many reputed journals. She conducted many workshops and completed many research projects. She received many awards like State Award in Medicine (1989), Medal of Excellence from the Egyptian Government (1994). She is an active member of Egyptian Society of Cancer, International Society of Hematology, European and African division (ISH), European Association of Hematology (EHA), American Association of Cancer Research (AACR), International Society of Thrombosis and Hemostasis (ISTH).

 

Abstract:

Cell-free indicates DNA that is found freely in the blood without a nucleus. Circulating cell-free DNA (ccf-DNAs) were first identified by Mandel and Metais in 1948 but their association with disease was not confirmed till 1977 when their increased level in the plasma/serum of cancer patients was proved. In healthy individuals, the main source of ccf-DNA is apoptotic cells which release uniform DNA fragments 185 to 200 base by a programmed enzymatic cleavage; the level is extremely variable but is usually low to negligible. Cancer cells release different and longer DNA fragments resulting from necrosis, autophagy, or mitotic catastrophe; the chance of an active release from cells was also reported and the levels are much higher than in healthy individuals. However, increased levels of ccf-DNA were observed in many diseases including leukemia, solid tumors, pulmonary embolism, myocardial infarction, tissue trauma, and chronic inflammatory diseases. This broad prevalence of diseases with potentially elevated ccf-DNA levels limits the diagnostic specificity and no cutoff value of plasma DNA concentration produced performance characteristics that would make it a good screening tool for neoplastic diseases. Thus a more refined approach was applied by calculating the ratio between cancer cell-derived ccf-DNA and normal cell-derived ccf-DNA in what is called DNA integrity index. More recently detection of tumor-specific molecular aberrations in the ccf-DNA is performed, what is called liquid biopsy. Many studies reported increased serum concentration and DNA integrity index in various solid tumors including breast, gynecological malignancy, HCC and acute myeloid leukemia. The analysis of the length of circulating DNA in plasma was reported as a sensitive marker for solid tumor detection and it was claimed to discriminate between benign and malignant lesions. The rationale of liquid biopsy is that mutations detected in ccf-DNA are highly specific of cancer and can clearly identify circulating tumor DNA (ct-DNA). Ct-DNA was explored as a prognostic or predictive marker for cancer detection; the studies suggested potential clinical applications. The analysis of ct-DNA ranges in scale from single mutations to whole-genome analyses. Liquid biopsy has many advantages compared to conventional sampling methods. The latter is subject to procedural complications, difficulty in obtaining sufficient material of adequate quality for genomic profiling and sampling biases that arise from genetic heterogeneity. A liquid biopsy is also superior to the conventional monitoring methods namely tumor markers that often lack specificity and imaging which exposes patients to ionizing radiation and has limited resolution. Promising as it is ccf-DNA and ct-DNA assays need scrupulous standardization to overlap discrepancies in sensitivities across various studies. However, sample collection is convenient, minimally invasive, and it avoids the need for tumor tissue biopsies. Analyzes of ccf- DNA and ct-DNA may have the potential to complement or replace existing cancer tissue and blood biomarkers in the future.

 

 International Conference Keynote Speaker Stef Stienstra photo
Biography:

Stef Stienstra works internationally for several medical and biotech companies as Scientific Advisory Board Member and is also an active Reserve-Officer of the
Royal Dutch Navy in his rank as Commander (OF4). For the Dutch Armed Forces, he is CBRNe Specialist with focus on (micro) biological and chemical threats
and Medical- And Environmental Functional Specialist within the 1st CMI (Civil Military Interaction) Battalion of the Dutch Armed Forces. For Expertise France, he
is now managing an EU CBRN CoE public health project in West Africa. In his civilian position, he is at this moment developing with MT-Derm in Berlin (Germany)
a novel interdermal vaccination technology as well as a new therapy for cutaneous leishmaniasis for which he has won a Canadian Grand Challenge grant. With
Hemanua in Dublin (Ireland), he has developed an innovative blood separation unit, which is also suitable to produce convalescent plasma for Ebola virus disease
therapy. He has finished both his studies in Medicine and in Biochemistry in the Netherlands with a Doctorate and has extensive practical experience in cell biology,
immuno-haematology, infectious diseases, biodefense and transfusion medicine.

Abstract:

Sharing security threat information is a challenge for governments and their agencies. Especially in biotechnology and microbiology the agencies do not know how to classify or to disclose collected information on potential bio-threats. There is vague border between man-made and natural biological threats. An example is the several month delay of the publication of research on the transmissibility of H5N1 avian influenza virus in the leading scientific journal Science by researchers of the Erasmus Medical Centre in Rotterdam, The Netherlands. The publication was delayed in 2012 by several months due to the fact that various organizations first wanted to investigate whether the details could be misused by malicious individuals. In the study the researchers show that only a small number of mutations were necessary to change the H5N1 virus so that it can spread through the respiratory system between mammals. This implies that the risk of a H5N1 pandemic cannot be ruled out. On the other hand, this information can be used to develop new therapies and/or vaccines for influenza. It gives also insight into the disease mechanism, which helps in the prevention. The same arguments are valid for therapeutic antibodies, like the antibodies, which are developed to treat anthrax. They have an extreme high affinity for the lethal factors of the bacterium and stop the disease, but the same antibodies could be misused to select the most pathogenic strains. Micro-organisms have from nature itself the capacity to reorganise and change their pathogenicity, which could lead to a pandemic spread of a disease. But if the disease is too infectious and too deadly, like some stains of Ebola Virus are, the lethality will be locally limited. But if the incubation time is longer in a certain strain of an Ebola virus, the risks on epidemics and even a pandemic is much higher. The knowledge of these natural mutation mechanisms could be misused to weaponize micro-organisms. It enables the engineering of the lethality like it is done with some anthrax strains. Are these laboratory techniques considered as public science or should it be classified? Academics want to publish and to share information for the progress of science and to find useful applications. The Rotterdam scientists were really annoyed when their research was blocked for publication and feared that other groups would be first in publishing a part of their obtained experimental results. Biosafety is already common practice in micro-biology, but biosecurity is often still questionable. A ‘Code of Conduct’, like the Dutch Academy of Science has developed, would help; especially for the so-called insider risk. Educational programs for the identification and assessment of risks and threats to security have to be developed to give scientists bio-threat awareness and for government officials to rationalize the real threat, without damaging the progress of science.

Keynote Forum

James Ratcliff

Rowpar Pharmaceuticals, USA

Keynote: Chemotherapy and oral sores
 International Conference Keynote Speaker James Ratcliff photo
Biography:

James Ratcliff is Chairman of the Board and CEO of Rowpar Pharmaceuticals, Inc., Scottsdale, AZ, maker of the Dentists Choice and ClōSYS brands of oral care products.
In 2014, Rowpar received the US Small Business Administration’s Exporter of the Year Award. From 1989 to 2000, he served as Senior Research Scientist, Professor and
Director, Center for the Study of Higher Education at the Pennsylvania State University. From 1979 to 1989, he was Professor and Program Head for higher education at
Iowa State University. He is the author of 120 articles, books, book chapters, is co-inventor on over 24 patents and patents pending. He is active Member of the Arizona
Biotechnology Assn., American Academy of Oral and Systemic Health, American Education Research Assn., and the International Association for Dental Research. He
holds a PhD in Higher Education from Washington State University, a MA in History from Washington State University, and a BA from Utah State University.

Abstract:

Mouth sores, mouth ulcers, or Oral Mucositis (OM) are abrasions of the mucosal layer of the oral cavity. OM is an
important issue for cancer patients since most patients undergoing chemotherapy or radiation therapy face a risk of
developing OM. In some patients these ulcers become so severe that they have to delay or discontinue the cancer treatment.
Th e objective of the project was to conduct a systematic search for most prevalent drugs and type of cancers associated with
OM, a knowledge not well documented. Our research on the extent of cancer drugs leading to OM revealed that about 38 drugs
cause OM in >30% of the patients. Secondly, an analysis of number of drugs that cause OM in diff erent cancers revealed that 20
drugs cause OM in breast cancer, 19 in lung cancer, 16 in non-Hodgkin’s lymphoma, 13 in acute lymphocytic leukemia, 12 in
melanoma and 11 in ovarian cancer. Further, the data from NCI website revealed fi ve cancers – Bladder, breast, colorectal, lung,
and prostate – Encompass a signifi cant population of patients that are suff ering from OM induced by chemotherapy. Oft en
medical professionals circumvent OM by maintaining good oral health e.g., by regular use of oral rinse. However, most oral
rinses contain alcohol and cannot be used by patients with OM. ClōSYS oral rinses are alcohol free, sulfate free, pH balanced
and contain stabilized chlorine dioxide. Because of its non-irritating nature and antibacterial and sanitizing properties of
stabilized chlorine dioxide, ClōSYS unfl avored oral rinse is most appropriate choice for circumventing OM in cancer patients.
About 40 customers and 140 Dentists and Hygienists responded to our survey. Most respondents recorded relief using ClōSYS
oral rinse in conditions such as dry mouth and mouth sores.

 International Conference Keynote Speaker Eugenie Bergogne Berezin photo
Biography:

Deanna Mulvihill has her expertise in evaluation and passion for improving the health and wellbeing. Her open and contextual evaluation model based on responsive constructivists creates new pathways for improving healthcare. She has built this model after years of experience in research, evaluation, teaching, and administration both in hospital and education institutions. The foundation is based on fourth-generation evaluation (Guba & Lincoln, 1989) which is a methodology that utilizes the previous generations of evaluation: measurement, description and judgment. It allows for value-pluralism. This approach is responsive to all stakeholders and has a different way of focusing.

 

Abstract:

2014,17,01, an Editorial entitled “Planetary viral extension” underlined the insufficient attention of Occidental Countries to the 20 EBOLA epidemics within 30 years, with 9936 cases and 4877 deaths. Guinea, Liberia, Sierra Leone were the most contaminated populations. Starting in Guinea WHO announced 2000 deaths. A French investigation published in 2007 had described a blaze-off epidemics only in 1995 in Kinshasa West with 250 deaths. Since then a brutal development of the disease extremely contagious has gained a rapid geographical extension in all Sub-Saharan Africa, Zaire, Soudan as well as West African countries. A worldwide interest in the disease (the journal TIME in 2014 “now arriving the deadly Ebola virus lands in America” (death was waiting for the traveler). Four major analyzes: (a) Epidemiology: including local surveillance, containment measures, WHO and journals of instant information. (b) Measures Since 2007: CDC-Mobile laboratories, surveillance of suspects or alerts or probable  (febrile or hemorrhagic or deaths cases) (immediately notified). (c) The office of “rumors” (news) (WHO: gloves, javel, mosquitos). Ebola is transmitted directly by contact, imposing the “salut EBOLA” (EBOLA fistful). (d) Funerals major source of contamination with traditional cleaning, embalms in close contact with the body and family members. Containment, surveillance, education, hygiene, medical personnel are current. WHO “Staff at the  outbreak sites see evidence that the nimbers of reported cases and deaths underestimate the magnitude of the outbreak.”

 

Keynote Forum

Dr.Ananda K J

Karnataka Veterinary, Animal and Fisheries Sciences University,India

Keynote: Coccidian Parasites of Public Health Importance
 International Conference Keynote Speaker Dr.Ananda K J photo
Biography:

Dr. Ananda, K. J. has completed PhD in Veterinary Parasitology at the age of 30 years from Veteinary College, UAS, Bangalore, Karnataka, India & rendered 12 years of service in teaching and research, specialized in Immunological and Molecular Diagnosis of Parasitic diseases. Presently working as Associate Professor & Guided four PG students & bestowed with Best Research Paper and poster award in National Conferences & published more than 45 research papers in both International & National Journals. He was the recipient of University gold medal for Ph.D and handled 05 research project and presently with two extramural research projects.

 

Abstract:

Coccidian parasites are known to infect a wide variety of animals, including humans, birds and livestock. They are usually species-specific, but the well-known exceptions are toxoplasmosis caused by Toxoplasma gondii and cryptosporidiosis caused by Cryptosporidium parvum. The zoonotic coccidian parasites known to cause disease in humans belong to the genus Cystisospora, Cryptosporidium, Toxoplasma and Sarcocystis respectively.

Cystisospora belli is the only species of Cystisospora that infects man and is frequently responsible for “traveller’s diarrhea”. C. belli is found throughout the world but is more common in tropical and subtropical regions. This disease is typically mild in healthy individuals but can be life threatening in people who are young or immunodepressed. Cystisosporosis was largely ignored until its recent emergence as one of the opportunistic infections affecting AIDS patients.

Toxoplasmosis is an opportunistic infection in humans caused by protozoan parasite Toxoplasma gondii, widespread globally and responsible for serious complications in individuals with impaired immune defences as well as congenitally infected infants. The high prevalence rate in some parts of the world coupled with the current drug treatments that trigger hypersensitivity reactions makes the development of immunotherapeutic interventions a highly important research priority. Immunotherapeutic strategies could either be a vaccine which would confer a pre-emptive immunity to infection, or passive immunization in case of recurrent clinical diseases. As the severity of clinical manifestations is often greater in developing nations, the development of well-tolerated and safe immunotherapeutic becomes not only a scientific pursuit, but a humanitarian enterprise. In the last few years, much progress has been made in vaccine research with new antigens, novel adjuvants, and innovative vaccine delivery such as nanoparticles and antigen encapsulations.

Cryptosporidium is increasingly gaining attention as a human and an animal pathogen mainly due to its dominant involvement in worldwide waterborne outbreaks. Ingestion of oocysts can cause gastrointestinal disease in immunocompetent and immunosuppressed human patients and those working with animals, including farmers and veterinarians, are considered to be at increased risk. Efforts to minimise transmission in people handling infected animals should include instruction regarding, and rigorous attention to, hygiene, protective clothing and efforts to disinfect contaminated areas.  

Sarcocystis spp. have indirect life cycle with an intestinal infections occur in the definitive host, and tissue invasion is seen in the intermediate host. Three species viz., Sarcocystis hominis, S. heydorni (intermediate hosts: cattle) and S. suihominis (intermediate hosts: pig) have been identified where humans serve as definitive hosts and get infected by ingesting raw or undercooked beef and pork respectively. Although others may exist, till now only S. nesbitti has been identified in humans serving as intermediate hosts based on 18S ribosomal DNA (rDNA) sequence analysis. Though the life cycle of S. nesbitti remains unknown, this zoonosis is linked to ingestion of food and water contaminated with the sporocysts of this species.

Keynote Forum

Elias El Haddad

University of Turin, Italy

Keynote: Soft tissues around implants and teeth
 International Conference Keynote Speaker Elias El Haddad photo
Biography:

Elias El Haddad is a Freelancer and Owner of  El Haddad Dental Clinic in Turin, Italy. He is a Scientific Manager of the Periodontology Department U.O.A of Odontostomatology Complex Structure of Dentistry and Maxillofacial Surgery, Martini Hospital, Turin. He completed his Graduation in Medicine and General Surgery at University of Turin; specialized in General Pathology at University of Turin and; completed Post-graduation in Implantology and Periodontics at the New York University. He dedicated himself to Implantology since 1988 following numerous courses in Italy and abroad.

Abstract:

A reduced or non-existent keratinized mucosa around the natural teeth and around the implants can promote inflammation of the mucous membrane plaque, the risk of bone resorption, the soft tissue dehiscence and also the loss of clinical attack. Managing patient requests with success that meets function and esthetics in reconstructive periodontology is among the biggest challenges in dentistry. The restoration of the keratinized tissue around the natural teeth is a technique that guarantees excellent functional and aesthetic results, in the long term very predictable. Despite the controversies, which still exist today in the literature, the presence of a good quality and quantity of keratinized tissue around the implants is necessary to prevent inflammatory phenomena such as mucositis and periimplantitis. In this report the simplest surgical techniques will be examined. Safe clinical outcome at a distance, combined with various clinical cases of rehabilitations on natural elements and implants.    

Recent Publications

  1. E El Haddad1, D Lauritano, V Candotto and F Carinci (2016) Implant-Abutment leaking of the replace conical connection with the Nobel biocare implant system. An in vitro study of the microbiological penetration from the external environment to the implant-abutment space. Oral Implantol.  9(2): 76–82.

 

 International Conference Keynote Speaker John M Jemison photo
Biography:

John M Jemison is an Extension Professor of Soil and Water Quality. He conducts applied research and educational outreach programs to encourage growers and homeowners to implement practices to improve soil quality and protect surface and ground water supplies. With projects like the Orono Community Garden, he teaches volunteers to grow food using organic practices and understand civic agriculture. His agricultural research focuses on nutrient and weed management strategies to improve soil health and crop productivity, integrating crop and livestock operations, reducing crop production impact to water resources and increasing resilience of cropping systems to change climate through reducing tillage and improving soil health. He is also a Cooperating Professor with the School of Food and Agriculture.

Abstract:

Maine farmers have become increasingly concerned about variable weather conditions affecting current and long-term productivity. In 2011, we conducted 15 focus groups in a program called ‘Assessing Maine’s Agricultural Future - 2025’ and we asked farmers: What changes are you making on your farm relative to recent weather patterns? As one might expect, responses ranged from challenging us that weather is indeed more variable now than previously, to others saying that they had adopted numerous practices including no-till production, purchased irrigation equipment and installed tile drainage. Fruit producers, particularly apple and blueberry growers were most concerned about variable weather, while potato and
dairy producers seemed least concerned and more entrenched with their production methods. Since then, we have developed a focused applied research and extension outreach effort to dairy and potato growers to work on improving soil quality to increase climate resilience. While cold wet soils were once thought to prohibit, no-till production in Maine, some dairy farmers even in northern parts of Maine have adopted the practice. We recently surveyed early adopters to find out why they changed and sampled fields to assess soil health. While most mentioned reduced fuel use, labor and time as key drivers, some discussed improving soil quality. Interestingly, we asked farmers to identify fields they wanted information on soil health and to tell us which fields they thought would have the best and worst soil health scores. They were correct, only 40% of the time indicating that they don’t fully understand soil quality. Our efforts to make potato production systems more resilient have
centered on reducing tillage where possible (such as one-pass hilling), evaluating the use of nurse crops to protect soils before
plant emergence, adopting longer rotations and integrating crop and livestock farms. Key field experimental results will be highlighted in the presentation.

 International Conference Keynote Speaker Weiqiu Chen photo
Biography:

Weiqiu Chen received his BS and PhD degrees from Zhejiang University in 1990 and 1996, respectively. He worked as a postdoctoral Research Associate at The University of Tokyo during 1997-1999. He was promoted as an Associate Professor in 1999 and a full Professor in 2000. He has engaged himself in the mechanics
of smart materials/structures and vibration/waves in structures for over twenty years. He has co-authored over 350 peer reviewed journal articles and three monographs. He now serves as the Editorial Member/Associate Editor in chief of 12 academic journals including Mechanics of Advanced Materials and Structures, Journal of Thermal Stresses and Composite Structures.

Abstract:

Soft electroactive materials can deform to a large extent in a reversible way under mechanical or electrical loading. This unique ability makes them very attractive to be the material candidates for designing smart and tunable devices, structures and systems. We will report some recent advances in tunable soft Phononic Crystals (PCs) in which waves can be manipulated according to the application purpose. In particular, attention will be paid to a simple one-dimensional soft PC cylinder made of dielectric elastomer. A series of mechanically negligible soft electrodes are placed periodically along the dielectric elastomer cylinder and hence the material is actually uniform in the undeformed state as well as in the uniformly pre-stretched state subjected to a static axial force only. Th e periodicity of the structure that is required for a PC is acquired via two diff erent loading paths. In the fi rst path, we fi x the ongitudinal stretch and then apply an electric voltage over any two neighboring electrodes. In the second path, the axial force is kept unchanged and then the voltage is applied. Th e outstanding performance regarding
the band gap (BG) property of the soft dielectric PC is well demonstrated through the comparison with the conventional design
adopting the hard piezoelectric material. We also illustrate that the snap-through instability of the axially free PC cylinder made of a generalized Gent material may be used to trigger a sharp transition  in the BGs.

 International Conference Keynote Speaker Manuel Alvarez Cuenca photo
Biography:

Dr. Alvarez Cuenca is a Professor of Chemical Engineering and Director of the Water Technologies Laboratory at Ryerson University (Toronto, Canada). He holds a B.Eng (Chemical Engineering) from the Universidad Politecnica de Madrid, and an M.Sc. and a Ph.D. in Physics and Chemical Engineering respectively from the University of Western Ontario (Canada). Manuel adds to his curriculum over 15 years of industrial experience with multinational corporations in the areas of fluidized bed reactors, bioreactor design, water treatment and clean power generation. In 2002, he founded Ecotechnos Inc., a company devoted to the design and construction of advanced bioreactors for the treatment of industrial watewater including nitrogen and phosphorous removal. He is an active consultant for both, governments and the private sector in Canada, Spain and Iberoamerica in the areas of water treatment, and energy. His academic record spans over three decades with universities in Europe, Canada, and South America, including Ryerson University, U. of Western Ontario, U of Waterloo, U. of Guelph, U of Windsor, U.Politécnica de Madrid ( Spain), Universidad Nacional de Colombia (Colombia), U de Cartagena de Indias (Colombia), Corporacion Universitaria de la Costa (Colombia).

E-mail: [email protected], [email protected]

Abstract:

The availability of water quality and quantity are facing an unprecedented crisis created by explosive demographic growth and overuse. Hence urban and industrial scarcity, limited construction surface and increasing chemical complexity of contaminants, like nutrients, microplastics, endocrine disruptors, etc. Contaminated water is defined here as water not suited for direct human consumption or industrial utilization whose composition has deleterious effects on either human health or the environment. The recovery of water for human utilization presents an unprecedented challenge. That recovery demands effective reactors, of reduced power consumption, demanding little construction surface for retrofitting and refurbishing.

Historical records show that contaminated water has been treated to achieve potability for thousands of years. The treatment was only physical (sand filtration) but in more recent times contaminated water has been treated chemically and biologically, or the physical treatment has become more complex.

Planar bioreactors (Often called aeration tanks) of circular or rectangular cross section have been the first choice for water engineers. Furthermore, in the last few decades, the kinetics of the processes, the control and instrumentation, and the reactor design of the biochemical reactors involved have become more precise and sophisticated.

The purpose of this presentation is to describe the STAR process including the application of the Multistage Vertical Bioreactor (USA Patent 8,585,900 B2) to the elimination of nutrients in contaminated water.
 

This bioreactor developed in the Department of Chemical Engineering of Ryerson University (Canada), offers powerful features associated to its performance removal, construction materials, reduced planar construction space, geometry and modular configuration. The simultaneous removal of both ammonia and total phosphorous exceeds 93 % for each contaminant. Two abundant microbial groups Saprospirasae (unidentified species) and Zoogloea are responsible for the simultaneous removal of ammonia and total phosphorous in the process
 

 International Conference Keynote Speaker Per Jensen photo
Biography:

Per Jensen is professor of theoretical chemistry at the University of Wuppertal, Germany. His research interests lie in the border area between high-resolution molecular spectroscopy and quantum chemistry. He develops and applies methods for the accurate simulation of rotation-vibration spectra of small molecules, mostly of astrochemical and/or atmospheric interest. He is particularly interested in the application of molecular symmetry to facilitate the solution of nuclear-motion problems. Recently, he has worked extensively on interactions between electronic states (the Renner effect), the characterization of rovibrational energy clusters at high rotational excitation, and extremely flexible (structureless) molecules. He is author or co-author of about 200 publications.

Abstract:

Traditionally, molecules are theoretically described as near-static structures rotating in space. Vibrational motion causing small structural deformations induces a perturbative treatment of the rotation-vibration interaction. This treatment fails in highly flexible molecules, where all vibrational motions have amplitudes comparable in size to the linear dimensions of the molecule. An example is protonated methane (CH5+). For these molecules, customary theory fails to simulate reliably even the low-energy spectrum. Within the traditional view of rotation and vibration being near-separable, rotational and vibrational wavefunctions are symmetry classified separately in the molecular symmetry (MS) group. All MS groups discussed so far are isomorphic to subgroups of the special orthogonal group in three dimensions SO(3). This leads to a group theoretical foundation of the technique of equivalent rotations. The group G240 (the MS group of protonated methane) represents, to the best of our knowledge, the first example of an MS group which is not isomorphic to a subgroup of SO(3). Because of this, a separate symmetry classification of vibrational and rotational wavefunctions becomes impossible in this MS group, consistent with the fact that a decoupling of vibrational and rotational motion is impossible. The talk will discuss the consequences of this and propose an alternative description making use of the fact that G240 and SO(3) are both subgroups of the group SO(5) of rotations in five-dimensional space. We take SO(5) to be a near-symmetry group for CH5+ and develop a theoretical model that successfully explains recent experimental observations of rotation-vibration transitions in cold CH5+. Two of the vibrational degrees of freedom are essentially free and, in an initial approximation, these vibrations are combined with the “usual” rotation in 3D space with the resulting motion being viewed as free rotation in 5D space, consistent with the symmetry group SO(5).

Figure 1: The effect of the proton permutation (15432) on a CH5+ ion. It rotates the quantization axis z and so the customary technique of equivalent rotations cannot be applied.

Keynote Forum

Stef Stienstra

Civil-Military-Interaction-Command Royal Dutch Armed Forces, Netherlands

Keynote: Zoonotic diseases threat needs sharing of information and new diagnostic systems in less developed countries
 International Conference Keynote Speaker Stef Stienstra photo
Biography:

Works internationally for several medical and biotech companies as a scientific advisory board member and is also an active reserve-officer of the Royal Dutch Navy in his rank as Commander (OF4). For the Dutch Armed Forces, he is CBRNE specialist with a focus on (micro)biological and chemical threats and medical- and environmental functional specialist within the 1st CMI (Civil Military Interaction) Battalion of the Dutch Armed Forces. For Expertise France he is now managing an EU CBRN CoE public health project in West Africa. He is visiting a professor at the University of Rome Tor Vergata giving lectures for the CBRN Master study. In his civilian position, he is at this moment developing with MT-Derm in Berlin (Germany) a novel intradermal vaccination technology as well as a new therapy for cutaneous leishmaniasis for which he has won a Canadian ‘Grand Challenge’ grant. With Hemanua in Dublin (Ireland) he has developed an innovative blood separation unit, which is also suitable to produce convalescent plasma for Ebola Virus Disease therapy. He has finished both his studies in Medicine and in Biochemistry in The Netherlands with a doctorate and has extensive practical experience in cell biology, immuno-hematology, infectious diseases, biodefense, and transfusion medicine.

Abstract:

Sharing public health threat information is a necessity for governments to prevent outbreaks of infectious diseases. Zoonotic
diseases are the most dangerous for outbreaks running out of control, as the population does not have natural nor artificial (from vaccination) immune response to new emerging diseases. The recent Ebola Virus Disease outbreak in West Africa was such an example. New diagnostic methods, which can be performed in developing countries lacking critical infrastructure have to be developed to have an early response on (potential) outbreaks. It must be high tech with high reliability, which can be used in rural areas without proper infrastructure. The mitigation of highly infectious and deadly disease pandemics have to be recognized at the source. Sophisticated diagnostic equipment and good calibration, maintenance and interpretation of the results is essential. To identify pathogens at molecular level new technologies are under development. In developing countries military and civilian actors cooperate fruitfully in fighting potential biological threats. In this civil-military cooperation it is not only the biosafety, which has to be considered, but also the biosecurity, as misuse of extremely dangerous strains of
microorganisms cannot be excluded. Several zoonotic infectious diseases, like anthrax, small pox and also the hemorrhagic fevers like Ebola Virus Disease are listed as potential bioweapons. With this extra threat in mind, both biosafety and biosecurity have to be implemented in all mobile or fixed clinical laboratories. An information/computer network with a cloud in which essential information can be traced, helps in early detection of outbreaks of ‘new’, mostly zoonotic, infectious diseases. The same technology helps in the forensic aspects in case of a bioterror attack.

 International Conference Keynote Speaker Vinit Wankhede photo
Biography:

Dr. Vinit Wankhede is a Consultant Pediatric Neurologist and Epileptology’s, currently practicing in Nagpur City in the state of Maharashtra, India. He has done his MBBS from Government Medical College and Hospital, Nagpur. He completed his DCH from BJ Medical College, Pune and DNB from Choithram Hospital & Research Centre, Indore. He underwent fellowship training in Pediatric Neurology & epilepsy at Bharati Hospital & Research Centre, Pune. He received honors and gold medals in his master's educations from Maharashtra University of Health Sciences and also from Neurology chapter of Indian Academy of Pediatrics for 1st rank in India. Currently, he is editor of the Indian Journal of pediatric neurology and has organized various Pediatric Neurology seminars, workshops, and conferences.

Abstract:

Introduction: Pilot studies and results of a meta-analysis of randomized controlled trials in neonates with ischemic encephalopathy have reported that therapeutic hypothermia decreases the mortality and improves the neurological outcome of neonates with perinatal asphyxia. However as servo controlled equipment to deliver therapeutic hypothermia is extremely expensive, we assessed the low-cost delivery method using cool packs. We also studied the problems and complications associated with this technique of maintaining sustained hypothermia.

Materials and methods: This was a prospective observational study conducted at NICU after ethical committee clearance. Inclusion criteria were 1.Gestational age > 36wks, 2.Birth weight > 2 kg, 3.Age < 6 hours, 4. Documented moderate to severe birth asphyxia defined in the study protocol. After obtaining informed consent from the parents, the neonates underwent cooling by using ice packs. The core temperature of the baby was recorded by inserting an oesophageal probe. All supportive management was started as per our NICU protocol. The core temperature of the neonates was monitored serially till the total period of 84 hours. Serial laboratories were obtained at the time specified by the protocol. After 72 hrs, the neonates were rewarmed slowly to a normal core temperature by 0.5°C every hour. Thereafter detailed daily examination was noted till discharge.

Results: Of 32 neonates admitted with perinatal asphyxia in1 year study period, only 6 were eligible for therapeutic hypothermia. The mean time taken to achieve target oesophageal temperature in 6 patients who underwent therapeutic hypothermia was 90 minutes. Mean oesophageal temperature was 33.75˚C and could be maintained for 72 hours with the use of cool packs. Rewarming phase took mean of 6 hours 45 min± 55min. Adverse events observed during cooling were sepsis, coagulopathy, hyponatremia, hypotension and abnormal renal function.

Conclusion: We have demonstrated that it is feasible to deliver therapeutic hypothermia using a low-cost model of room temperature modulation and ice packs in resource-limited settings. However, the adverse events may limit its use in resource-limited settings.

Keynote Forum

Vinod Labhasetwar

Lerner Research Institute, USA

Keynote: Simple is better in nanomedicine
 International Conference Keynote Speaker Vinod Labhasetwar photo
Biography:

Vinod Labhasetwar, PhD, is a Professor of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, both in Cleveland, Ohio, USA. The primary research focus of his laboratory over the past 25+ years has been on nanoparticle-mediated drug delivery in the context of translational and clinical medicine, particularly focusing on disease conditions where no effective treatments yet exist. His team’s specific interests are in developing effective approaches to cancer therapy (against drug resistance and metastasis), cardiovascular diseases (particularly inhibition of restenosis), and facilitating neuromuscular repair mechanisms in stroke and spinal cord injury. Recently, his group’s efforts have been expanding into two new areas: retinitis pigmentosa, with the goal of slowing the progression of photoreceptor degeneration; and transplantation research, with the objective of extending the critical window of time for organ preservation. He has published over 180 peer-reviewed articles and book chapters. He is listed among the 2014 and 2015 Highly Cited Researchers by Thomson Reuters, based on the top 1% of citations during the past 10 years. He has over 25 issued US and international patents and 4 provisional the US patents filed/pending. He is Editor-in-Chief of Drug Delivery and Translational Research, an official journal of the Controlled Release Society.

 

Abstract:

Nanoparticle-based drug delivery systems can potentially overcome several barriers to drug delivery, reduce toxicity to the patient, and thus improve therapeutic outcomes. Over time, nanoparticles have undergone evolution from simple to more complex systems, yet the nanoparticle formulations developed as “nanomedicine” for clinical use remain quite simple. Our laboratory research has shown that simple nanoparticle formulations, developed with a solid rationale, are very effective in treating complex conditions. This overview will describe nanoparticles that are straightforward in design yet effective in treating complex diseases in animal models. One example is a formulation that successfully treats bone metastasis, considered the primary cause of death in many types of cancers but more particularly in prostate and breast cancers. A second example is a formulation that effectively modifies the after-effects of stroke. This presentation will also define the challenges in moving complex nanoparticles through regulatory pathways and the scale-up process toward eventual commercialization.

Keynote Forum

Ron Hart

University of Rutgers, USA

Keynote: will be updating soon
 International Conference Keynote Speaker Ron Hart photo
Biography:

Ron Hart has done his B.S. in University of Connecticut, Storrs, CT and Ph.D.in University of Michigan, Ann Arbor, MI. He has done his postdoctoral training under William Folk, advisor from University of Michigan, Ann Arbor, MI and Joseph Nevins, advisor from Rockefeller University, New York, NY. He is the Director of Human Genetics Institute of New Jersey Stem Cell Program and Co-Chair in Rutgers University Institutional Biosafety Committee.

Abstract:

Keynote Forum

Armen B Avagyan

Research & Industry Centre of Photosynthesizing Organis, Armenia

Keynote: Climate change, necessities of change in global environmental policy and microalgae application
 International Conference Keynote Speaker Armen B Avagyan photo
Biography:

Doctoral degree of Moscow State university. He worked as Senior researcher Armenian Institute of Agriculture and Technological Institute of Amino Acids of USSR,director of Armenian Institute of Biotechnology, director of Yerevan Vitamin plantand deputy director of Nairit Chloroprene Rubber plant. Sole founder of Research &Industry Centre of Photosynthesizing Organisms, Feed Additives & Physiologically Active Compounds; Expert of EU Horizon 2020, ERA.NET and International Cooperationprograms and Council of Chemistry and Petrochemistry of CIS countries. AcademicMember of the Greece ATINER Academia, Member of American Chemical Society and Society of Chemical Industry (USA),  Member of Editorial Boards of journals:“Journal of Chemical, Environmental and Biological Engineering" (USA),SM Journal of Environmental Chemical Engineering" (USA) and Modern Management Forum (Singapore). Laureate of “The International Presidents Award for Iconic Achievement” and “Top 100 Professionals” (IBC, England), "The Albert Einstein Award for Excellence" (Top 50 Geniuses of World, ABI, USA), Marquis Who's Who “2017 Albert Nelson Marquis Lifetime Achievement Award” (USA), awards of the Armenia and former USSR

 

 

Abstract:

During action of the Kyoto Protocol the GHG emissions are growing of about 52 billion tons CO2 per year or up 58% from 1990. The UNEP fixed that even if all countries deliver on the Paris Climate Agreement, the world will warm by 3.0 to 3.2°C. The UN’s top Climate change officials, Addis Ababa Action Agenda and the Marrakech Partnership for Global Climate Action declare as imperative action - multi-stakeholder partnerships and the attraction of the private sector investment for fast track development of Climate change mitigation.  However, they did not offer effective and equitable policy component for Global market partnership based on the payments to the private companies for mitigation of Climate change impact. Such payments fund must be developed from the incomes of pollution taxes, etc. and will serve economical effective increasing of investments in the development of the Global Life Conserve Industry. This will allow also mitigate market penetration influence (as falling oil prices on today’s biofuel market).

The technological approach must base also on the algae CCS technology. The microalgal production of 417,659 tones can absorb up to 0.764 MtCO2eq (in addition, reduction of NOx and VOCs) and produce 0.559 MtO2eq with a decreasing of Canadian producers carbon taxes up to US$ 764–1528 billion per year. This quantity of microalgae can used as feed additive (1%) and will meet the total demand of Canada on 213%, USA on 25%, or Europe on 20% per year. Microalgae-derived biofuel can reduce GHG emission for Canada on 71-106 MtCO2 per/year.

The development of the microalgae Live Conserve Industry is principal step from non-efficient protection of the environment to its cultivation in a large scale with mitigation of GHG emission and waste as well as generating of O2 and value-added products by the use of opens an important shift towards a new design and building of a biological system


 

 

 

Keynote Forum

Christelle Kadlec

Institute of Physics, Czech Academy of Sciences, Czech Republic

Keynote: Departure from BCS response in photoexcited superconducting films observed by terahertz spectroscopy
 International Conference Keynote Speaker Christelle Kadlec photo
Biography:

C Kadlec obtained her PhD in Plasma Physics from the University of Orleans, France. She works as a Researcher in the Institute of Physics in Prague, Czech Republic in the field of THz spectroscopy, where she is considered as an expert in thin films. She is a co-author of more than 60 publications.

Abstract:

We investigate thin superconducting NbN films with various thicknesses by time-resolved terahertz spectroscopy. In agreement with previous reports, the equilibrium THz conductivity can be described by the BCS theory. Upon strong photoexcitation by femtosecond laser pulses, when the superconducting state is completely broken, the recovery dynamics occurs by a growth of initially spherical isolated superconducting islands in the normal-state environment. These islands subsequently merge towards a nearly percolated superconducting network. The recovery process is accompanied by a shift in the conductivity spectral weight, indicating a departure from the BCS character of the density of electron states in these islands. While the superconductivity recovers on the hundreds-picosecond time scale, the properties characterizing the superconducting state (such as the gap width and the density of states) recover much more slowly, at least on the nanosecond time scale.

 International Conference Keynote Speaker Sheikh Jan Mohammad photo
Biography:

Sheikh Jan M is the Consultant Cardiologist (MD. DNB –Senior Resident Cardiology,Batra Hospital and Medical Research centre, New Delhi, India.

 

Abstract:

Background: An early diagnosis of myocardial infarction is highly important in the emergency department (ED). It facilitates rapid decision making and treatment and therefore improves the outcome in patients presenting with symptoms of chest pain. 

Aims and Objectives: To study diagnostic utility of new point of care high sensitive troponin-I assay in early diagnosis of acute myocardial infarction in patients presenting with acute chest pain.

Materials and methods: Forty six consecutive patients of acute onset chest pain who presented to our cardiac emergency department within three hours of symptom onset were enrolled for study.POC Hs Trop-I test was done on admission (0 hour), and after 3 hours if initial test result was negative. Quantitative troponin I (Q-Trop I) lab assay was done on admission (0 hour), 3 hours and 6 hours after admission. Six hour Q-Trop I assay was taken as gold standard for the initial diagnosis of AMI. The final adjudicated diagnosis of AMI was based on a composite of ECG changes (new ST segment or T wave changes, new onset LBBB), Troponin results, Echocardiography (new wall motion abnormality), angiographic findings (detection of a culprit lesion) and final chart review of observations made.

Results: Comparing the results of POC Hs Trop I results at 0 hour with the gold standard test we found the sensitivity of 97%, specificity of 100%, positive predictive value (PPV) of 100% and negative predictive value (NPV) of 92.3%. Sensitivity of POC Hs Trop I at 3 hours was better than POC Hs Trop I at 0 hour (97 vs. 100%) and equal to gold standard i.e. 100 %.Specificity, PPV and NPV are 100% for POC Hs Trop I at 1 hour.

Conclusion: High sensitive Trop I test is rapid and reliable method to diagnose and exclude acute myocardial infarction in patients presenting with acute onset chest pain to our EmergencyDepartments.

 International Conference Keynote Speaker Randall E Merchant photo
Biography:

Randall E. Merchant, Ph.D. has been a Professor of Anatomy and Neurosurgery at Virginia Commonwealth University since 1982. Dr. Merchant and his team of colleagues
have conducted several clinical investigations on the effects of dietary supplementation with chlorella in patients with various chronic illnesses. Dr. Merchant continues to be
in the forefront of double-blind, placebo-controlled clinical research on chlorella. He serves as a Member of Health & Science Advisory Board of Sun Chlorella USA Corp.
Dr. Merchant earned his Doctoral and Master of Sciences degree from the University of North Dakota with a major in Anatomy, minor in Immunology

Abstract:

Keynote Forum

Shavonne Massey

Children’s Hospital of Philadelphia, USA

Keynote: Considerations in the diagnosis and treatment of neonatal seizures
 International Conference Keynote Speaker Shavonne Massey photo
Biography:

Shavonne Massey is an Attending Physician in the Departments of Neurology and Pediatrics at The Children’s Hospital of Philadelphia and The Perelman School of Medicine at The University of Pennsylvania in Philadelphia, PA. She is a Pediatric Epileptologist with clinical and research interests in the management of brain injured neonates. Within this neonatal population, her specific interests are the use and value of the electroencephalogram in the diagnosis of seizures, development of neurophysiologic biomarkers for brain injury and outcomes, management of seizures, and development of predictive strategies and modeling for acute and chronic outcomes in this population.

Abstract:

Over 800,000 neonates suffer brain injury yearly and seizures are the most common clinical manifestation. Seizures are common during the neonatal period due to age-dependent mechanisms that favor excitability in the immature brain. There are a myriad of potential causes for neonatal seizures, but acute causes, such as hypoxic ischemic encephalopathy, stroke, hemorrhage, and infection, are most common, accounting for up to 80% of cases. The recognition of neonatal seizures is important because seizures are associated with unfavorable acute and chronic outcomes. In the past, seizures were diagnosed clinically, but with growing recognition of the very high subclinical seizure burden that exists in the neonatal population, the electroencephalogram (EEG) is now the gold standard for diagnosing and managing neonates at high risk for seizure occurrence. With the use of EEG, more neonates with seizures are identified bringing considerations in the management of neonatal seizures to the forefront of neonatal care. While there is a growing body of literature on the occurrence and diagnosis of neonatal seizures, many questions remain about the best ways to manage neonatal seizures. Developing best practices for the management of neonatal seizures is of paramount importance given that the mere presence of neonatal seizures can worsen the neurodevelopmental trajectory. This session will review the epidemiology and etiologies of neonatal seizures, as well as the diagnosis of neonatal seizures and the important role of the EEG in accurately diagnosing seizures. The session will also review outcomes data from basic and clinical models of neonatal seizures. The majority of the session will focus on specific considerations in the treatment of neonatal seizures, including when to treat seizures, the mechanisms and data supporting the use of specific antiseizure medications, novel antiseizure medications currently under investigation, and the presence and effect of variability in the treatment of neonatal seizures

 International Conference Keynote Speaker Joel I. Osorio photo
Biography:

CEO & Founder - Biotechnology and Regenerative Medicine at RegenerAge International ™ (www.regenerage.clinic) VP of International Clinical Development for Bioquark, Inc.

(www.bioquark.com) Chief Clinical Officer at ReAnima™ Advanced Biosciences (www.reanima.tech) Westhill University School of Medicine.

Mexico Advance Fellow by the American Board of AntiAging and Regenerative Medicine (A4M)

Visiting scholar at University of North Carolina at Chapel Hill (Dermatology) Fellow in Stem Cell Medicine by the American Academy of Anti-Aging Medicine and University of South Florida

 

Abstract:

As it has been previously demonstrated that coelectroporation of Xenopus laevis frog oocytes with normal cells and cancerous cell lines induces the expression of pluripotency markers, and in experimental murine model studies that mRNA extract (Bioquantine® purified from intra- and extra-oocyte liquid phases of electroporated oocytes) showed potential as a treatment for a wide range of conditions as Squint, Spinal Cord Injury (SCI) and Cerebral Palsy among others. The current study observed beneficial changes with Bioquantine® administration in a patient with a severe SCI. Pluripotent stem cells have therapeutic and regenerative potential in clinical situations CNS disorders even cancer.2-3- 7 One method of reprogramming somatic cells into pluripotent stem cells is to expose them to extracts prepared from Xenopus laevis oocytes1 We showed previously that coelectroporation of Xenopus laevis frog oocytes; with normal cells and cancerous cells lines, induces expression of markers of pluripotency.4 We also observed therapeutic effects of treatment with a purified extract (Bioquantine) of intra- and extra-oocyte liquid phases derived from electroporated X. laevis oocytes, on experimentally induced pathologies including murine models of melanoma, traumatic brain injury, and experimental skin wrinkling induced by squalenemonohydroperoxide (Paylian et al, 2016).

The positive human findings for Spinal Cord Injury, and Cerebral Palsy with the results from previous animal studies with experimental models of traumatic brain injury, respectively (Paylian et al, 2016). Because of ethical reasons, legal restrictions, and a limited numbers of patients, we were able to treat only a very small number of patients. These results indicate that Bioquantine ® may be safe and well tolerated for use in humans, and deserves further study in a range of degenerative disorders. We propose that the mechanism of action of Bioquantine® in these various diseases derives from its unique pharmacology and combinatorial reprogramming properties. In conclusion, these preliminary findings suggest that Bioquantine is safe and well tolerated on patients with Cerebral Palsy and- Spinal Cord Injury, among others. In addition to the regenerative therapy and due to the patient condition, we decided to include the Restore- Sensor SureScan5-6 . Based on the of electrical stimulation for rehabilitation and regeneration after spinal cord injury published by Hamid and MacEwan 8-9 , we designed an improved delivery method for the in situ application of MSCs and Bioquantine® in combination with the RestoreSensor® SureScan® Conclusions: To the present day the patient who suffered a total section of spinal cord at T12-L1 shows an improvement in sensitivity, strength in striated muscle and smooth muscle connection, 11 months after the first therapy of cell regeneration and 3 month after the placement of RestoreSensor ® at the level of the lesion, the patient with a complete medullary section shows an evident improvement on his therapy of physical rehabilitation on crawling from front to back by himself and standing on his feet for the first time and showing a progressively important functionality on the gluteal and legs sensitivity

 

 International Conference Keynote Speaker Zoella Vlamaki photo
Biography:

Trained In General Surgery, Laparoscopic Surgery, Endocrine Surgery and Breast Surgery, starting her work studies and training, in Athens Greece, Hippokration General Hospital. She developed her interest in diagnosis and treatment of breast diseases and breast cancer, advancing breast surgical Oncoplastic skills and breast reconstruction when she moved on to UK in 2001, working in NHS England. She has a broad international experience working in different continents of the glob. With her passion following Hippocratic principles, her interest spread to Integrative medicine in prognostic and preventive medicine and wellbeing. She became, American board Certified in Wellbeing and Anti aging doctor. Her Practice and the Biovitality clinic integrates breast cancer diagnosis and treatments. Biovitality Clinic aims for everyone body and mind health. She continues to work as a Consultant Breast Surgeon. The Biovitality clinic has the passion to know you, create your individual path of wellbeing, beauty of body and mind for a bright future.
 

Abstract:

 International Conference Keynote Speaker Aby J Mathew  photo
Biography:

Aby J Mathew was part of the founding team of BioLife Solutions, Inc., and is a co-developer of BioLife’s biopreservation media solutions. He has been researching low-temperature biopreservation since 1994, and his studies contributed to the development of BioLife’s current commercial HypoThermosol® and CryoStor® product platforms and intellectual property foundation. He was BioLife’s first Director of Manufacturing, established BioLife’s initial quality system, and is currently Senior Vice President & Chief Technology Officer. He is a member of AABB, BEST Collaborative, ISCT, ARM, TERMIS, and the Society for Cryobiology. He is a member of the Board of Directors and the Advisory Panel of the Parent’s Guide to Cord Blood Foundation, the Scientifi c Advisory Board of HemaCare Corporation, the founding Board of Directors of the Cord Blood Association, the NIST-AMTech National Cell Manufacturing Consortium, and the California Institute for Regenerative Medicine (CIRM) Clinical Advisory Panel. 

Abstract:

Cellular therapies, regenerative medicine, and biobanking utilize cell and tissue products sourced from blood, bone marrow, and various tissues. Th e clinical and commercial utility of these products is potentially impacted by stability limitations, which include transport of the source material and biopreservation of the fi nal cell or tissue product (either frozen or non-frozen). Oft en in cell and tissue processing, there may exist a gap between biopreservation method optimization from a cryobiology perspective and the process development that results in the cryopreserved or non-frozen cell/tissue product. Traditional home-brew reagent cocktails (including serum) utilized for biopreservation are a point of risk within a GMP clinical manufacturing process and may be suboptimal options in comparison to pre-formulated GMP intracellular-like formulations. Th is discussion will off er best practices recommendations for integrating biopreservation methods within Good Manufacturing Practices (GMP), share lessons learned from cell therapy manufacturing and biobanking, and off er suggestions for integration of biopreservation methods within biobanking and regenerative medicine with consideration to the quality and regulatory footprint. Topics include best practices in optimizing biopreservation workfl ow, including transportation and storage of source material and fi nal dose, post-preservation assessment variability, and evaluation, selection, and validation of ancillary and excipient reagents.
 

 International Conference Keynote Speaker Christina YK Leung photo
Biography:

Christina Leung completed two Bachelor degrees in England, BSc Management Sciences followed by the BPharm Pharmacy. Following the registration as a pharmacist in the UK, she worked in different London Teaching Hospitals for 16 years. In UK, she specialised in Paediatrics (especially in PICU and Paediatric Liver), Obstetrics and Gynaecology. She published a number of articles including drugs use in paediatric liver diseases in the UK and management of vomiting in pregnancy and hyperemesis gravidarum. Ms Leung is also a registered pharmacist in Hong Kong. Since 2012, she had worked as the Senior Pharmacist (Clinical Pharmacy in Charge) at the University of Hong Kong-Shenzhen Hospital, a reformed hospital in China. Currently, Ms Leung is the Honorary Tutor at the University of Hong Kong. She delivers lectures to the Master and Undergraduate Pharmacy students relating to drugs use in Paediatrics, Obstetrics and Gynaecology.

Abstract:

Biliary atresia (BA) is a condition in which infl ammation develops within the bile ducts around the time of birth. This leads to bile duct damage and reduces the fl ow of the bile which subsequently causes scarring of the liver. The initial treatment for biliary atresia is a surgical operation called the “Kasai Porteoenterostomy” (KPE). The aim of KPE is to make a drainage channel to allow bile to drain from the liver. Before the surgery, the patient will be prescribed with fat-soluble vitamins for patients with prolonged jaundice. Examples are multivitamin preparations (Abidec® or Dalivit® drops in the UK), vitamin K preparations (phytomenadione injection which can be given by oral, IV or IM routes and menadiol tablet), Vitamin E (tocopheryl acetate), and Vitamin D (Alfacalcidol). 24 to 48 hours before the surgery, the patients will receive bowel preparations and the common ones are Lactulose liquid, Neomycin liquid, and Metronidazole suspension. Aft er the operation, the patient will receive drugs via intravenous or intramuscular route for about 3 to 5 days, standard maintenance IV fl uid will be given for about 3 to 4 days. Nurse Controlled Analgesia (NCA) IV pump with morphine is always used for the initial 3 days, and the patient is also prescribed with regular paracetamol (IV or rectal) for breakthrough pain for about 3 days then change to oral. Prophylactic IV antibiotics will be given aft er the surgery for at least 72 hours. Examples are Gentamicin and Piperacillin/Tazobactam as dual therapies. Aft er 72 hours, if no high temperature is developed and the oral feeds are started, the prophylactic antibiotics can be changed to oral for 28 days (an example is oral Cefalexin). Ranitidine is also used to prevent a stress-induced ulcer. Intramuscular vitamins are used post-surgery. Examples are Vitamin D 30,000 units (60,000 units if radiological rickets is present), Vitamin E 10mg per kg, Vitamin A 10,000 units are given at the discretion of hepatologist (usually for patients with late diagnosis). Aft er day 5 of operations, the patient may start oral therapies. Additional oral vitamins
are necessary post-surgery for about 6 months. Examples are Vitamin K, Vitamin E, and multivitamin drops. Oral Phenobarbitone (alcoholfree liquid or tablet) helps to increase bile fl ow and hence to reduce itching symptom. Th e recommended dose is 15mg daily, increasing to 45mg daily in steps of 15mg per week. Colestyramine helps to remove the bile salts which cause jaundice and itchiness. Since Colestyramine can reduce the absorption of some drugs, especially vitamins, it is recommended to leave vitamin preparations at least 2 hours before or 4 hours after giving Colestyramine. Spironolactone suspension helps the patient reduces the amount of fl uid accumulated as a result of ascites, but it is not needed in all cases. Th ere have been clinical studies to use high dose oral steroids (oral prednisolone) post KPE to benefi t in reduction of postoperative bilirubin and clearance of jaundice. However, the fi ndings show that the eff ect of steroids may be limited or inhibited by an increasing degree of fi brosis and onset of cirrhosis. If KPE is successful, many of these medicines can be stopped over time. If KPE fails, the liver transplant can be one of the treatment options. Th e care of the biliary atresia patients is best with the multi-disciplinary approach, and clinical pharmacists play a signifi cant role in this care management. Examples of the contributions are dosage recommendations, choice of drugs, stopping or initiation of a therapy, guidelines development, drug history talking and medication reconciliation, therapeutic drug monitoring and other blood results monitoring to optimise drug therapies, patient education such as developing of patient leafl ets and delivering of patient education talks, patient counselling of discharged medications such as using of tailored-made discharge medication card, discharge planning to reduce the waiting time, adverse drugs reactions monitoring, medication incidents management, drugs interactions, advice on drug administration (e.g. with or aft er food, timing of drug administration, method of IV drug administration), review of medications in the out-patient clinics aft er discharge, and participation in the clinical trials.

Keynote Forum

Regina Folster-Holst

Past President of European Society for Pediatric Dermatology, Germany

Keynote: Anetodermic pilomatricoma in a 14-year old boy
 International Conference Keynote Speaker Regina Folster-Holst photo
Biography:

Regina Fölster-Holst is Professor at the Department for Dermatology, Venereology and Allergology at the Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany. She obtained her medical degree at the Christian-Albrechts-Universität, Kiel and is board certified in dermatology and allergology. She is a member of the German Dermatology Association (DDG), where she leads the Society of Pediatric Dermatology. She is executive board member of the European Society of Pediatric Dermatology (ESPD), a member of the Institute for Medical and Pharmaceutical Examination (IMPP) and engaged in the occupational union of the German Dermatologists e.V. (BVDD). Her scientific focuses are paediatric dermatology, allergic diseases and parasitoses, whereas the main trust of her research is in atopic dermatitis, with special research expertise in immunological and biochemical activity markers, prognostic criteria, epidemiological researches and new therapeutical strategies. Prof. Dr. Regina Fölster-Holst has received numerous awards, such as the Hans-Karrer-Förderpreis (medical brochure for children) in 1997, the “Preisder Hensel Stiftung” (1998), theTeaching Award of the Medical Faculty of Kiel (2003), the German scientific award for communication and the Perle-Award.

Abstract:

The anetodermic pilomatricoma, also known as bullous pilomatricoma is a special very rare variant of pilomatricoma which we saw in a 14-year old boy. Th e tumors occur later (adolescence, young adult) compared to the classical form (3-8 years) and are characterized by a red dome-shaped nodule with a superfi cially soft (anetodermal-like) and a very firm deep portion of the tumor. Th e diagnosis is verifi ed by histology, which shows edematous tissue overlying a deep otherwise typical pilomatricoma consisting of typical anucleate eosinophilic squamous cells (ghost cells) in the center, foreign body giant cells and basaloid cells with basophilic nuclei of the periphery. The presence of calcifi cations with foreign body giant cells is common within the tumors. Th erapy of choice is complete excision of the tumor.

 International Conference Keynote Speaker Hilla Yaniv photo
Biography:

Hilla Yaniv is a PhD student at Bar Ilan University, Ramat Gan, Israel, and has a Master’s degree in Clinical Social Work from the Hebrew University of Jerusalem, Israel. She works as a Social Worker in Rehabilitative Agency, which accompanied individuals who cope with different mental disorders, in their rehabilitation process in the community.

Abstract:

The lecture will present a research investigates the connection between creativity and aggression in different mental disorders, and examining their mutual influence on each other, in reference to Eysenck's three dimensions of personality, as well as to other personality's traits. The study examines five different groups: (1-2) individuals dealing with mental disorders - with or without a background of aggression; (3) creativeindividuals;
(4) aggressive-individuals; (5) and a control group. The main
comparison focuses on examining cognitive psychopathology, which leads the positive aspect to creativity on the one hand and the negative aspect to aggression on the other hand. These topics are investigated by using various questionnaires as well as by the microgenetic-method, which uses visual stimulation, in these study artworks. By using this method, it is possible to investigate the influence of visual perception of stimuli and the way individual projects his or her inner world and personality is tested
by examining the projection content toward the stimulus. The expectation is to find relationship between creativity and aggression, especially in psychopathology groups. This relationship connects broadly to the psychoticism dimension of Eysenck's three personality dimensions, which is also expected to be high among the pathologies groups. These pathology populations were deliberately chosen because they are on the extreme expression of various personality traits and dimensions, particularly the aspects related to measures of creativity and aggression. Consequently, psycho-therapy for those populations can be suited specifically to the individual's profile, using different creative therapy methods. First results will be presented.

Keynote Forum

Joachim Maier

Max Planck Institute for Solid State Research, Germany

Keynote: The connection between chemistry and electric function in solids
 International Conference Keynote Speaker Joachim Maier  photo
Biography:

Joachim Maier studied Chemistry at the University of Saarbrücken, received his PhD in 1982 from the same university and completed his Habilitation at the University of Tübingen in 1988. He has lectured at the University of Tübingen, at Massachusetts Institute of Technology as a foreign Faculty Member, at the University of Graz as a Visiting Professor, and at the University of Stuttgart as an Honorary Professor. He is Past President of the International Society of Solid State Ionics. As Director of the Physical Chemistry Department (since 1991) of the Max Planck Institute for Solid State Research and Member of various national and international academies his concern is the conceptual understanding of chemical and electrochemical phenomena involving solids as well as their use in materials science. He has been listed as one of the most influential scientific minds (Thomson Reuters).

 

 

Abstract:

In loose terms chemistry is the chemistry of the perfect state (perfect crystallographic structure) plus chemistry of the excited state (defect structure). The latter is responsible for the electric transport and storage properties. In aqueous solutions this function is taken by H+ and OH- ions as well as dissolved ions. In solids this role is carried out by point defects such as excess (interstitials) and lacking particles (vacancies). It is exactly the consideration of point defect chemistry which is necessary to understand and tune ionic transport phenomena in solids hence forming the bridge between chemistry and electric function. This picture also comprises the electronic transport enabled by excess electrons and electron holes. It is shown how the charge carrier chemistry can be understood, analyzed and varied as a function of stoichiometry and doping not only in the bulk but also at interfaces. Of special interest are size effects on the electronic and ionic carrier concentrations. These defect-chemical considerations directly translate into the electric function in batteries, fuel cells and photo-electrochemical devices. This does not only hold at or near equilibrium, also the kinetic performance depend on such issues. In addition to transport-related questions, the point defects are most relevant acid-base or redox-active centers and are thus of central significance, not only for transport, but also for reaction kinetics and catalysis. A selection of applied examples such as storage modes in batteries, reaction kinetics in fuel cells or transport effect in photo-perovskites will be addressed.

 

 International Conference Keynote Speaker Bernadette Curry photo
Biography:

Bernadette D Curry is Dean Emerita and Professor at Molloy College. She holds a Baccalaureate degree from Niagara University, a master’s degree in Nursing from
the State University of New York at Buffalo, a PhD in Educational Administration, Organization and Policy from the University at Buffalo, and a Certificate in Leadership
from Harvard University. In addition, she has been inducted as a Fellow into the American Academy of Nursing. She was presented a medal by the French Navy in
recognition for achievement in nursing education. She has been an active participant and officer in a variety of professional organizations including Sigma Theta Tau
International, American Nurses Association (ANA), International Network for Doctoral Education in Nursing (INDEN), American Assembly for Men in Nursing (AAMN),
American Association for French Speaking Health Professionals, Greater New York, Nassau, Suffolk Organization of Nurse Executives. She sits on several boards, serves
as a Commission for Collegiate Nursing Education (CCNE) Team Leader for evaluation of nursing programs, mentors doctoral students, and participated in the first Taking
Care at the Bedside (TCAB) national initiative. She has published a variety of articles, including those requested for repository in the Jean Piaget Archives in Geneva,
Switzerland and McGill University in Montreal, Canada. Currently, she is writing a book on Doctoral Education, and recently completed a study on the Motivation of Men in
Nursing to Pursue the PhD degree. She has been an ardent advocate for men in nursing which is one area of interest. Other interests include leadership, professionalism,
image of nursing, higher education, and marketing.

Abstract:

The purpose of this study is to explore the motivation of men in nursing to pursue a PhD. It is a qualitative study using a
phenomenological approach that involves interviews with men who are practicing nursing and currently enrolled in PhD
programs, or are alumni. Deans of nursing schools were asked to recommend participants for the purposive sample. These
individuals were contacted, and the sample consisted of 12 men in the Eastern region of the US. Interviews were conducted at the
participant’s educational institution, place of employment, or by phone. Consent was obtained for recordings, and transcriptions
were kept in a locked file. All identities and related information has been kept confidential. Data was analyzed for themes and
notable elements of motivation. This study provides insight into the machinations and meaning of the decision among an underrepresented
segment of the nursing profession. The results highlight the influences, both internal and external, on decision
and timing. The information is significant to nursing because it may hold potential to increase the male population of nursing,
incorporate the male perspective, enhance the scholarly image, and advance the professional functions of the discipline. Doctorally
prepared nurses are the bedrock of nursing research, the designers of policy for healthcare, and the conduit of education for
current professionals and the future of the profession.

Keynote Forum

Ronald Naumann

Max Planck Institute of Molecular Cell Biology and Genetics,Dresden,Germany

Keynote: Managing a successful transgenic mouse facility under Full-cost accounting
 International Conference Keynote Speaker Ronald Naumann photo
Biography:

Ronald Naumann received Diploma as graduate engineer in 1993 from Fachhochschule Anhalt Bernburg; Germany. Before his military service, he received education as zoo technician from 1984 to 1986. He started his career as Manager for agriculture in estate Kaltenbrunn, Germany.In 1995 he joined Max Planck Institute of Biochemistry as Foreman and animal breeder in 1995. Over the years, Ronald had established mutiple successful transgenic facilities within Europe. He founded transgenic facilities at University of Manchester in 2001, at European Institute of Oncology, Italy in 2005, at University of Freiburg, Germany in 2011 and at University of Jena, Germany in 2015. Currently, Ronald is the Group Leader of Transgenic Core Facility at Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany since 2002.

Abstract:

Today, the mouse is a widely used animal model in the scientific community. The Transgenic Core Facility (TCF) at the MPI-CBG provides a centralized resource and stateof-the-art technology in production of Knock-Out (-IN) mice by injection or aggregation of embryonic stem cells into mouse embryos, and transgenic mice by injection of DNA or CRISPR into the cytoplasm or pronuclear of mouse zygotes. Our transgenic service facility generated about 70 mutant mouse lines per year. As backups in any cases, we use sperm freezing and embryo freezing to store all our mouse lines in safety conditions. We work very successful and efficient in full cost accounting. I would like talk about management, 3R's animal welfare, budget, animal and personal resources and the generating of mutant mice in a high health level (SPF). We show that using of fresh or frozen mouse embryos from breeding companies as donor for ES-cell injection is a flexible tool to provide customized projects. All the CRISPR, plasmid or BAC injections into zygotes will made in specific user background to reduce the numbers of re-crossing generations. An important role as facility leader is also the motivation of employees through it’s effective incentive plans so that the employees provide fullest co-operation.

 International Conference Keynote Speaker Michaelene Holder March photo
Biography:

Mrs Holder-March, is a goal driven healthcare executive with over 31 years of leadership and training experience. She is also well known and respected in the UK and USA for her professionalism, her vast experience and portfolio of managing Corporate & Clinical Governance, Information Governance, Risk Management, Operations, System Resilience, Claims, Audit and Health and Safety in both the public and private healthcare sector. Drawing on her experience working with a wide range of companies of all sizes, from all sectors, Michaelene is an enthusiastic and inspirational coach, also a strategic advisor in the reorganising companies and advising CEOs and senior management, specialises in revitalising companies, ensuring that business objectives are achieved through having the right people in the right roles. Michaelene Gail Holder-March is a qualified teacher, nurse & midwife with registrations both in the UK & USA; she also holds a LLB and MBA in Management. She is a strong advocate of hands-on, inquiry based learning, she actively involves herself in a variety of charitable community service, mentoring /coaching others to follow her lead.

Abstract:

Technology is swiftly changing the landscape of care and delivery frameworks whereby healthcare organisations can now help patients through the utilisation  of  Internet  of  Things (IoT) technologies / systems to improve patients’ health outcomes and experiences by using rich health data and insights to enable a holistic patient diagnosis. Globally healthcare organisations are unconsciously challenged  to keep stride with patient behaviour and expectations for digitally mobile and accessible systems of care.

There are hurdles for healthcare organisations in regards to the deployment of Internet  of Things (IoT) Technologies this includes the lack of interoperability with current patient record electronic system, suppliers accountability  for failures, data  storage, consent and  data sharing, password protections and the management of the multiple connected devices from various suppliers. Other published hurdles are the tremendous quantity of  hospital  and multiple streams of patient data from various devices and readiness for the hospitals  information technology departments to manage data security, compliance with information governance, data regulations and cyber security which are to be risk managed on a daily  basis. Despite the hurdles  the benefits of fully embracing Internet  of  Things  (IoT) Technologies within healthcare is a welcome advancement in modern healthcare.

 International Conference Keynote Speaker Anil K Saxena photo
Biography:

A K Saxena, is actively involved in the domain of Medicinal Chemistry & CADD, drug discovery and development research. He has 45 years of research experience with 200 research publications, 19 reviews/articles in books and/monographs, 72 patents and has delivered >180 invited lectures, chaired >45 sessions. He is Fellow of Royal Society of Chemistry, UK, Editorial Board Member of different prominent journals like, Medicinal Chemistry Research, SAR and QSAR in Environmental Research, online International journal ARKIVOC, and Patent Evaluator: Current Drugs, UK. He is also series Editor for book series “Topics in Medicinal Chemistry” published by Springer Verlag.

Abstract:

In recent years tuberculosis (TB) chemotherapy is dependent on drugs targeting bacterial metabolism with bactericidal action having no effect on dormant or latent or metabolically inactive bacilli that target cell division. The ATP synthase is a ubiquitous enzyme in energy metabolism due to its involvement in the generation of sufficient amount of ATP and/or in generating a proton motive force (PMF) in mycobacteria during adverse conditions of low oxygen environment and nutrient deficiency. This pivotal role of ATP synthase is targeted by the diarylquinoline TMC207 that kills Mycobacterium tuberculosis. Utilizing the state-of-the-art medicinal chemistry approach the quinoline class of aryl-sulfonamides has been identified as potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors. Among a series of compounds synthesized which were effective in vitro on ATP synthase, the lead compound [N-(7-chloro-2-methylquinolin-4-yl)-N-(3-((diethylamino)methyl)-4-hydroxyphenyl)-2,3-dichlo-r obenzene sulfonamide] exhibited excellent selectivity (mycobacterium ATPase IC50 = 0.51 µM, mammalian ATPase IC50 >100 µM, and selectivity >200) and is also active in the hypoxic culture of non replicating M. tuberculosis at 100 µg/mL (32-fold of its MIC) as compared to positive control isoniazid [approximately 0.2 log10 reduction in CFU at 5 lg/mL (50-fold of its MIC)]. Docking of the best compound on homology modeled ATP synthase revealed the participation of the protonated tertiary amine and hydroxyl group to interact with the carboxylate oxygen of Glu61 that is similar to TMC207. The study provides a deep understanding about the structural requirements for ATP synthase inhibitors helpful in the discovery of novel chemical entities.

 International Conference Keynote Speaker Azza Mahmoud Kamel photo
Biography:

Azza Mahmoud Kamel is currently working as Emirate Professor of Clinical Pathology at National Cancer Institute, Cairo University, Egypt since 2007. Previously she worked as Professor of Clinical Pathology (1986- 2007) at National Cancer Institute, Cairo University, Egypt, Founder and Head of BMT Lab. Unit (1993- 2007) and Head of Clinical Pathology Department (2005-2007). She pursued her Medical Degree (MB, BCh), Faculty of Medicine, Cairo University (June 1968), Master Degree (MSc) in Clinical Pathology, Faculty of Medicine, Cairo University (October 1972) and Doctorate Degree (MD) in Clinical Pathology(Immunology/ Hematology), Faculty of Medicine, Cairo University (July 1976). She has 165 publications in many reputed journals. She conducted many workshops and completed many research projects. She received many awards like State Award in Medicine (1989), Medal of Excellence from the Egyptian Government (1994). She is an active member of Egyptian Society of Cancer, International Society of Hematology, European and African division (ISH), European Association of Hematology (EHA), American Association of Cancer Research (AACR), International Society of Thrombosis and Hemostasis (ISTH).

 

Abstract:

Cell-free indicates DNA that is found freely in the blood without a nucleus. Circulating cell-free DNA (ccf-DNAs) were first identified by Mandel and Metais in 1948 but their association with disease was not confirmed till 1977 when their increased level in the plasma/serum of cancer patients was proved. In healthy individuals, the main source of ccf-DNA is apoptotic cells which release uniform DNA fragments 185 to 200 base by a programmed enzymatic cleavage; the level is extremely variable but is usually low to negligible. Cancer cells release different and longer DNA fragments resulting from necrosis, autophagy, or mitotic catastrophe; the chance of an active release from cells was also reported and the levels are much higher than in healthy individuals. However, increased levels of ccf-DNA were observed in many diseases including leukemia, solid tumors, pulmonary embolism, myocardial infarction, tissue trauma, and chronic inflammatory diseases. This broad prevalence of diseases with potentially elevated ccf-DNA levels limits the diagnostic specificity and no cutoff value of plasma DNA concentration produced performance characteristics that would make it a good screening tool for neoplastic diseases. Thus a more refined approach was applied by calculating the ratio between cancer cell-derived ccf-DNA and normal cell-derived ccf-DNA in what is called DNA integrity index. More recently detection of tumor-specific molecular aberrations in the ccf-DNA is performed, what is called liquid biopsy. Many studies reported increased serum concentration and DNA integrity index in various solid tumors including breast, gynecological malignancy, HCC and acute myeloid leukemia. The analysis of the length of circulating DNA in plasma was reported as a sensitive marker for solid tumor detection and it was claimed to discriminate between benign and malignant lesions. The rationale of liquid biopsy is that mutations detected in ccf-DNA are highly specific of cancer and can clearly identify circulating tumor DNA (ct-DNA). Ct-DNA was explored as a prognostic or predictive marker for cancer detection; the studies suggested potential clinical applications. The analysis of ct-DNA ranges in scale from single mutations to whole-genome analyses. Liquid biopsy has many advantages compared to conventional sampling methods. The latter is subject to procedural complications, difficulty in obtaining sufficient material of adequate quality for genomic profiling and sampling biases that arise from genetic heterogeneity. A liquid biopsy is also superior to the conventional monitoring methods namely tumor markers that often lack specificity and imaging which exposes patients to ionizing radiation and has limited resolution. Promising as it is ccf-DNA and ct-DNA assays need scrupulous standardization to overlap discrepancies in sensitivities across various studies. However, sample collection is convenient, minimally invasive, and it avoids the need for tumor tissue biopsies. Analyzes of ccf- DNA and ct-DNA may have the potential to complement or replace existing cancer tissue and blood biomarkers in the future.

 

Keynote Forum

Kenith Meissner

Swansea University, UK

Keynote: Ultrabithorax-based Materials
 International Conference Keynote Speaker Kenith Meissner photo
Biography:

Kenith Meissner received his PhD from the University of Arizona, Optical Sciences Center in the area of ultrafast spectroscopy and semiconductor physics. He then served as a Postdoctoral Appointee at Sandia Naitonal Labs. After spending 7 years in industry developing noninvasive blood gluscose technology, Prof. Meissner returned to academia with positions at Virginia Tech (USA), Texsas A&M University (USA) and Swansea University (UK). His research focuses on biomedical optics and micro-/nano-materials.

 

Abstract:

Ultrabithorax (Ubx) is a Drosophila melanogaster transcription factor protein the the Bondos group discovered has the ability to form ordered materials in vitro. Ubx monomers are produced in E.coli and, following purification, are suspended in a buffer solution and where they do not aggregate in the volume of the solution when refrigerated. When allowed to rest at room temperature, the monomer self assembles at the air/water interface through nucleation, fibril formation and, eventually, film integration. The the self assembled film can then be pulled into a fibre with diameters in the range of 2–50 μm or lifted off as a film with microscale thickness. These materials are highly elastic and maintain physical properties through cycles of drying and re-hydrating. Novel functions can be directly incorporated into Ubx-based materials via gene fusion to produce chimeric polypeptides capable of both self-assembly and the desired chemical reactivity. Unlike most protein-based materials, the gentle conditions under which Ubx self-assembles enable incorporation of active heterologous proteins. This talk will review recent work on the continued development of this unique materials system including mechanical properties enabled by dityrosine bonding between monomers, dynamics of surface film assembly, and advances in Ubxbased materials production.

Keynote Forum

Digdem Muge Siyez

Dokuz Eylul University, Turkey

Keynote: Investigating university students knowledge levels about infertility
 International Conference Keynote Speaker Digdem Muge Siyez photo
Biography:

Digdem M Siyez is a Professor in the Department of Counseling and Guidance at the Dokuz Eylul University in Turkey. She received her PhD in Counseling and Guidance at the Dokuz Eylul University. Her current research interests include Sexual Health, Gender, Adolescence Development and Prevention.

Abstract:

Statement of the Problem: Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Infertility is more pervasive in developing countries than developed countries. It is observed that studies on the level of knowledge about infertility in Turkey are very limited and these studies were carried out in small samples. The aim of this research was to examine the knowledge levels of university students on infertility.

Methodology & Theoretical Orientation: Participants were 9693 Bachelor’s students (51.6% female, 48.4% male) from 21 universities in Turkey. The data was collected via Infertility Knowledge Test which is developed by the researchers. The responses to the Infertility Knowledge Test, which consists of 33 items, are marked as "true", "false" and "do not know".

Findings: An important finding obtained from this study was 68.4% of the respondents knew that women’s fertility potential decreased after age 40 compared to 20 years old, while 10% of the participants knew that sperm quality in men deteriorated with age and 23.6% of the participants knew that age was a determining factor in male infertility. The majority of participants knew that smoking, drugs and exposure to heavy chemicals could cause infertility. More than half of the participants didn’t know that timing of sexual intercourse and being extremely weak could cause infertility.

Conclusion & Significance: It can be said that the participants' knowledge level about infertility was low and participants were not aware of some of the preventable risk factors related to infertility. For this reason, it is recommended that awareness raising activities should be undertaken.

Break: Networking & Refreshments Break 11:00-11:15 @ Foyer

Keynote Forum

Mahesh Baj

Portiuncula Hospital, Ireland

Keynote: Latest trends in breast imaging
 International Conference Keynote Speaker Mahesh Baj photo
Biography:

Mahesh Baj is an award-winning Consultant Radiologists with more than 40 years experience of teaching radiology in India, UK and Ireland. He holds 4 Postgraduate qualifications in Radiology including MD, DMRD, FRCR and FFRRCSI. He has written several research papers and book chapters. He is on the Editorial Board of many journals and Chairman of International Tele-Imaging Organization. He has received “Hind Rattan” Award from President of India in 2003.

Abstract:

X-ray mammography is still the gold standard for routine breast cancer screening due to its costs, speed and cancer detection accuracy. But it is estimated that up to 35% of cancers are overlooked and that 10-15% of screening exams require further testing due to inconclusive results, especially in dense breast. The accuracy of mammography screening in women with dense breast tissue is much lower approximately 75%. The new recommendation is to include breast ultrasound, breast Magnetic Resonance Imaging (MRI) and other exams deemed necessary by a physician. Ultrasound is within affordable costs, widespread availability, ongoing technological advancements and significant improvements in detection accuracy when used to supplement mammography. Ultrasound and mammography screening protocol has been demonstrated to increase the detection of cancers in the breast by 28%. Automated Breast Ultrasound (ABUS) continue to improve accuracy of ultrasound. MRI is very costly and not available freely. While MRI is commonly used in diagnostic and therapeutic breast imaging applications, tomosynthesis has perhaps attracted more attention than any other breast imaging technology in recent years due to its ability to improve cancer detection accuracy and reduce patient recalls when combined with mammography. It is very expensive. Tomosynthesis scans can be acquired in less than 20 seconds at the time of mammography but there are drawbacks including increased interpretation time and image data storage requirements, additional ionizing radiation per exam. Role of other modalities like MBI (Molecular Breast Imaging) and PET (Positron Emission Tomography) will be discussed.

Keynote Forum

Petra Perner

Institute of Computer Vision and Applied Computer Sciences, Germany

Keynote: Big Data, Decision Tree Induction, And Image Analysis For The Discovery Of Decision Rules For Colon Examination
 International Conference Keynote Speaker Petra Perner photo
Biography:

Petra Perner is the director of the Institute of Computer Vision and Applied Computer Sciences IBaI. She received her Diploma degree in electrical engineering and her PhD degree in computer science for the work on “Data Reduction Methods for Industrial Robots with Direct Teach-in-Programing”. Her habilitation thesis was about “A Methodology for the Development of Knowledge-Based Image-Interpretation Systems". She has been the principal investigator of various national and international research projects. Her research interest is image/signal analysis and interpretation, machine learning, data mining, big data, machine learning, image mining and case-based reasoning.

Abstract:

The aim of our research was to develop a method that allows us automatically to discover the decision rules for diagnosing images in normal and abnormal images. We used a dataset of images that came from an endoscopic video system used for colon examination.  The data set contains 283 normal tissue images and 61 polyp images. One must decide if the image shows a polyp or not.  This is a two class problem. The unequal number of the data in the two classes makes our problem to an unbalanced data set problem.  The polyps in the images were identified and selected by a “well-trained” medical expert. The 283 normal images consist of dark regions and reflection. We describe the images by our novel random set texture descriptor. The resulting data set was used to train a decision tree with our tool “Decision Master”. For the full unequally distributed data set we achieved an error rate of 9.88% based on cross-validation.  We achieved an error rate of 1.67% when we created a data set with equally distributed data in each class.  The results show that decision tree induction based on “Decision Master” and image analysis based on our novel texture descriptor is an excellent method to mine images for the decision rules even when the data set is unbalanced.  Our texture descriptor gives a flexible way to describe the appearance of the medical objects. The accuracy of the derived rules can be improved when the data set is made equally distributed.

 International Conference Keynote Speaker Ankita Tuknayat photo
Biography:

Ankita Tuknayat is pursuing her post-graduate residency in Dermatology in Government Medical College and Hospital, Chandigarh, India. She has 2 international publications namely Cyclophosphamide Induced Hearing loss – Reversibility and Preventive strategies in  American Journal of Therapeutics and Extensive Donor Site Keloids in Follicular Unit Extraction Hair Transplantation in International Journal of Trichology. She has presented various papers as Speaker and multiple posters in various dermatology conferences across India. She has also won a second award in a poster presentation in a national conference on Dermatophytosis conducted in Post Graduate Institute of Medical Education and Research in 2017. She is an avid participant in various activities of Chandigarh Dermatology Society.

 

Abstract:

Introduction

Terra firma forme dermatosis (TFFD) is an acquired, benign disorder of keratinization characterized by retention hyperkeratosis presenting as dirt like plaques which are resistant to washing but can be removed with forceful swabbing with alcohol pad. The exact etiopathogenesis of the disease is unknown but is thought to be due to delay in the maturation of keratinocytes, with melanin retention and accumulation of sebum &amp; corneocytes .

Case report

A 29 years old female presented with complaints of persistent brownish-grey dirt-like skin lesions over her face and neck along with matting of hairs from last 5 years for which she had taken multiple consultations but with no relief.Histopathology was consistent with TFFD. The lesions were wiped off with isopropyl alcohol, confirming the diagnosis. On enquiring she had some psychiatric issues for which she was evaluated.

 

Discussion

Dermatitis neglecta/passivata involves self neglect due to underlying psychological morbidity. This has not been described in the recently described TFFD . But in our patient a psychiatric component was elicited and histopathology was consistent with TFFD. This propels us to think that dermatitis neglecta and TFFD which is a new entity may be a continuum of the same spectrum.

 

 International Conference Keynote Speaker Marc Delcommenne photo
Biography:

Marc Delcommenne is currently an Director of Research and Development at MBL International / MBL Bion. He is also an professor works in Rush University Medical Center, Chicago. He has published many articles in reputed journals. His research interest includes Biology, Immunology & microbiology.

Abstract:

Rapid discovery and identification of many new and novel tumor associated epitopes and neoantigens can potentially result in potent cancer vaccines. However, no verdict of immunogenicity may be made without a rapid method to measure the binding of these peptides to MHC of the hosts.   While existing methodologies rely on UV cleavage of exiting peptide on monomeric MHC complexes and a subsequent lengthy tetramerization procedure, the platform presented here produces tetramers ready for cell staining to detect antigen-specific T cells in just four hours.  We have devised a fast and user-friendly peptide exchange tetramer platform (also referred as QuickSwitch™ Quant) that can both help determine binding of novel peptides, including neoantigens, to MHC class I molecules and generate new specificity MHC class I tetramers for peptide specific T cell detection.  We have developed a platform / kit for the generation of new specificity MHC tetramers, whereby a peptide of interest and a peptide exchange factor is incubated with a fluorescently labeled tetramer containing a special exiting peptide.  This study aimed to determine whether the peptide exchange HLA-A*02:01 tetramer platform can be used for evaluating the biological activity of a vaccine.  The tested vaccine was DPX-Survivac, an ovarian cancer vaccine candidate which consists of several survivin peptide antigens that are each restricted to a different human class I allele. We evaluated the specificity and sensitivity of the platform for assessing the biological activity of SurA2.M, an HLA-A2-restricted peptide, in DPX-Survivac.  We tested the detection of the peptide prepared individually in a buffered solution or in the DPX-Survivac vaccine prepared in an aqueous formulation.  Results indicate that peptide exchange rate of SurA2.M is similar whether it is dissolved individually in a buffered solution or in a matrix of the vaccine.  Thus, by optimizing a concentration curve using individual peptides, the peptide exchange tetramer platform can be used to examine the binding of peptide vaccines in a mixture and to quantify the concentration of HLA-A2 restricted peptides in simple solutions or more complex formulations. 

 International Conference Keynote Speaker Aram Cargill photo
Biography:

Aram Cargill is the director of The Adaption Apex Lab and Change Challenge working alongside Dr Kaalii Cargill who completed her PhD in psychology and Melbourne University Australia. She has been the past President of SCAPE (Society of Counselling and Psychotherapy Educators) and ISOCSS (International Society of Clinical and Counselling Supervisors), and past Vice-President of PACFA (Psychotherapy and Counselling Federation of Australia). As well as working in private practice (Kairos Centre ) for 40 years. Aram Cargill is also on the board of directs for Ledsen and an executive director a Kanga innovation. Working together the two have adapted DARE ( Deception Analysis Reasoning Engine ) for advanced lexical psychometric testing through mobile phone technology     

Abstract:

The digital age has made deception manipulative profiles far more attractive and simpler, not only for predatory behaviour but also in terms of the developing personality.

As the information age develops into the age of augmentation (Harris 2016 ), our understanding of ourselves becomes ever more relevant  as our digital identities grow in importance and stature.  

In the light of this, understanding what has been referred to as “the dark triad”  (Paulhus & Williams, 2002 ) or negative personality traits on a day to day, pedestrian level becomes ever more important. The very fact that our digital identities express not only our conscious choices but also our subconscious wants and desires and unconscious needs, it is important that our profile of the dark triad becomes more refined. If left in the “dark”, these traits may become evident in some type of externalised event. Narcissism, machiavellianism, and psychopathy are encouraged and exacerbated by technology (Twenge & Foster, 2010). These personality traits have become ever more alluring and seductive because of ability to construct digital identities that may take precedence over authentic identities.

We have steered away from general profiling and testing of these traits because of the criticisms of verbal descriptors of individual differences (lexical hypothesis) especially in in terms of the dark triad because of negative language and its impact on self-description.

The developments in artificial intelligence identify attitudes, emotions, and moods during lexical hypothesis testing, and give the framework greater extension and accuracy in trait profiling of individuals. This in turn gives more proficiency to language-based profiling of the dark triad. Developments in the cost-effectiveness of big data support this. 

Our society now requires greater base line awareness, observation, monitoring and management long before the deception manipulative profiles of the digital age hit the radar in negative consequences or predatory behaviour.