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Gottumukkala Krishna Mohan

Gottumukkala Krishna Mohan

Jawaharlal Nehru Technological University, India

Title: Biologically Synthesised Silver Nanoparticles from Momardica Charantia and Assessment of Antidiabetic Activity on Streptozotocin Induced Diabetic Rats

Biography

Biography: Gottumukkala Krishna Mohan

Abstract

Background, Object:

In recent research biological methods have been used to synthesize silver nanoparticles in presence of medicinally active antidiabetic plant and this intention made us to assess the biologically synthesized silver nanoparticles (BSSNP) from Momordica Charantia using 1 mM silver nitrate solution. The synthesised nanoparticles were characterized by Scanning electron microscope (SEM), Transmission electron microscope (TEM), UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). In current study the silver nanoparticles tested for in-vivo anti-diabetic activity in wistar rats.

Results and Discussion

XRD graph represents presence of peaks at 2θ values 28.1°, 33.09°, corresponds to (111), (200), (202), planes of silver, respectively. Thus, the XRD spectrum confirms the crystalline nature of BSSNP. From EDX it is clear that the strong signal of silver in the spectra, confirms the formation of silver nanoparticles. The result obtained from study indicates that silver nanoparticles synthesized using plant have shown potent activity than that of plant extract.

Conclusion

Biologically synthesized silver nanoparticles were successfully obtained from bioreduction of silver nitrate using Momordica Charantia plant extract and have been appropriately characterized using different equipments. From the study biologically synthesized silver nanoparticles exhibited strong antidiabetic effect against Streptozotocin (STZ) induced diabetic rats than that of extract. The approach of green synthesis seems to be cost efficient, eco-friendly and easy alternative to conventional methods of silver nanoparticles synthesis.

Key words: Biologically synthesized silver nanoparticles, Momordica Charantia, antidiabetic effect.